Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCZ | Q05513 | 1/20 | 0.43 |
| ▸ | IDO1 | P14902 | 3/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 10/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 10/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | CYP2B6 | P20813 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1478085 | 0.75 | PARP1 (0.36) | IDO1CYP11B2CYP11B1CYP3A4CYP2D6 | |
| SCHEMBL19259529 | 0.74 | KDM4E (0.47) | CYP1A2IKBKETBK1 | |
| SCHEMBL20873066 | 0.72 | PRKCZ (0.64) | PRKCZCYP11B2CYP11B1CYP3A4CYP17A1 | |
| SCHEMBL18148991 | 0.72 | CYP11B1 (0.50) | IDO1CYP11B2CYP11B1CYP3A4ADRA2A | |
| SCHEMBL1501931 | 0.72 | IDO1 (0.59) | IDO1CYP11B2CYP11B1CYP3A4ADRA2A | |
| SCHEMBL1528253 | 0.69 | PRKCZ (0.56) | PRKCZCYP11B2CYP11B1CYP3A4CYP17A1 | |
| SCHEMBL5571013 | 0.69 | HSD17B10 (0.53) | PRKCZCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL26053442 | 0.68 | KDR (0.51) | PRKCZIDO1CYP11B2CYP11B1CYP3A4 | |
| SCHEMBL450794 | 0.68 | TGFBR1 (0.39) | PRKCZCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL10806364 | 0.67 | PRKCZ (0.69) | PRKCZCYP11B2CYP11B1CYP3A4CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220133740-A1 | VALPROIC ACID COMPOUNDS AND WNT AGONISTS FOR TREATING EAR DISORDERS | Frequency Therapeutics, Inc. (US) | 2022-05-05 | — | — | US | disclosed |
| EP-1778225-A2 | PYRROLO(OXO)ISOQUINOLINES AS 5HT LIGANDS | Bristol-Myers Squibb Company (US) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006019886-A2 | PYRROLO(OXO)ISOQUINOLINES AS 5HT LIGANDS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2006-02-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220133740-A1 | VALPROIC ACID COMPOUNDS AND WNT AGONISTS FOR TREATING EAR DISORDERS | WNT3A, WNT1, WNT3 | PRKCZ 910/4885IDO1 2165/4885CYP11B2 1388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.