Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 3/20 | 0.31 |
| ▸ | RAB9A | P51151 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | APEX1 | P27695 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13217487 | 0.80 | RXFP1 (0.43) | RXFP1DAODYRK1ANPC1RAB9A | |
| SCHEMBL14690117 | 0.77 | NUDT1 (0.43) | RXFP1DAODYRK1AMEN1KMT2A | |
| SCHEMBL12778752 | 0.77 | RXFP1 (0.38) | RXFP1DAODYRK1ANPC1RAB9A | |
| SCHEMBL31275117 | 0.74 | RAB9A (0.38) | RXFP1DAODYRK1ANPC1RAB9A | |
| SCHEMBL7397856 | 0.73 | KDM4E (0.40) | RXFP1DAODYRK1ALMNAALDH1A1 | |
| SCHEMBL28563694 | 0.72 | KDM4E (0.47) | NPC1RAB9AMEN1KMT2ACYP3A4 | |
| SCHEMBL9693499 | 0.72 | ALDH1A1 (0.58) | NPC1RAB9AMEN1KMT2ALMNA | |
| SCHEMBL2815837 | 0.69 | ADRA2A (0.35) | MEN1KMT2ALMNAMAPTALDH1A1 | |
| SCHEMBL2299821 | 0.69 | AURKA (0.49) | DAODYRK1AMEN1KMT2ALMNA | |
| SCHEMBL13217758 | 0.68 | GFER (0.51) | RXFP1NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809628-B1 | PHENYLUREA DERIVATIVES USED AS INHIBITORS OF TYROSINKINASE FOR TREATING TUMORS | MERCK PATENT GMBH (DE) | 2011-06-08 | — | — | EP | disclosed |
| US-7696224-B2 | Phenylurea derivatives as inhibitors of tyrosine kinases for the treatment of tumour diseases | MERCK PATENT GMBH (DE) | 2010-04-13 | — | — | US | disclosed |
| US-20080207682-A1 | Phenylurea Derivatives As Inhibitors Of Tyrosine Kinases For The Treatment Of Tumour Diseases | MERCK PATENT GMBH (DE) | 2008-08-28 | — | — | US | disclosed |
| EP-1809628-A1 | PHENYLUREA DERIVATIVES USED AS INHIBITORS OF TYROSINKINASE FOR TREATING TUMORS | Merck Patent GmbH (DE) | 2007-07-25 | — | — | EP | disclosed |
| WO-2006042599-A1 | PHENYLUREA DERIVATIVES USED AS INHIBITORS OF TYROSINKINASE FOR TREATING TUMORS | MERCK PATENT GMBH (DE) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207682-A1 | Phenylurea Derivatives As Inhibitors Of Tyrosine Kinases For The Treatment Of Tumour Diseases | TIE1, RET, FLT1 | RXFP1 157/4885DAO 2059/4885DYRK1A 173/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.