Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 16/20 | 0.54 |
| ▸ | GCKR | Q14397 | 3/20 | 0.48 |
| ▸ | GCK | P35557 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12090262 | 0.91 | RORC (0.42) | RORC | |
| SCHEMBL18319 | 0.88 | GCKR (0.51) | RORCGCKRGCK | |
| SCHEMBL18549 | 0.88 | RORC (0.53) | RORCGCKR | |
| SCHEMBL19688 | 0.84 | RORC (0.53) | RORCGCKR | |
| SCHEMBL20078 | 0.83 | RORC (0.54) | RORCGCKR | |
| SCHEMBL18572 | 0.79 | RORC (0.56) | RORCGCKR | |
| SCHEMBL31484639 | 0.78 | GPR119 (0.52) | — | |
| SCHEMBL19271 | 0.78 | RORC (0.47) | RORCGCKR | |
| SCHEMBL12089736 | 0.77 | GPR119 (0.40) | RORCGCKR | |
| SCHEMBL15202876 | 0.77 | RORC (0.44) | RORCGCKR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027261-A1 | SULFONYLPIPERAZINE DERIVATIVES THAT INTERACT WITH GLUCOKINASE REGULATORY PROTEIN FOR THE TREATMENT OF DIABETES | AMGEN INC. (US) | 2012-03-01 | — | — | WO | disclosed |