SCHEMBL1927468

SCHEMBL1927468

O=C(NCc1cccnc1)c1cccc(Br)c1

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MEN1 O00255 1/20 0.64
▸ KMT2A Q03164 1/20 0.64
▸ NPC1 O15118 1/20 0.61
▸ L3MBTL1 Q9Y468 2/20 0.60
▸ NPSR1 Q6W5P4 2/20 0.60
▸ ALDH1A1 P00352 2/20 0.60
▸ USP2 O75604 1/20 0.60
▸ TSHR P16473 3/20 0.60
▸ HPGD P15428 2/20 0.60
▸ LMNA P02545 4/20 0.60
▸ HDAC2 Q92769 1/20 0.60
▸ HDAC8 Q9BY41 1/20 0.60
▸ HDAC6 Q9UBN7 1/20 0.60
▸ MAPT P10636 1/20 0.59
▸ HTT P42858 1/20 0.59
▸ MAPK1 P28482 1/20 0.58
▸ CYP1A2 P05177 1/20 0.58
▸ CYP3A4 P08684 1/20 0.58
▸ BLM P54132 1/20 0.58
▸ MMP13 P45452 1/20 0.58

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29818102 1.00 MEN1 (0.64) MEN1KMT2ANPC1L3MBTL1NPSR1
SCHEMBL14030202 0.86 L3MBTL1 (0.64) MEN1KMT2ANPC1L3MBTL1NPSR1
SCHEMBL13702277 0.86 L3MBTL1 (0.64) KMT2ANPC1L3MBTL1NPSR1ALDH1A1
SCHEMBL29818228 0.85 LMNA (0.62) NPC1L3MBTL1ALDH1A1TSHRHPGD
SCHEMBL7082686 0.84 TSHR (0.73) MEN1KMT2ANPC1NPSR1ALDH1A1
SCHEMBL3647370 0.84 ALDH1A1 (0.64) NPC1L3MBTL1NPSR1ALDH1A1USP2
SCHEMBL13947589 0.84 LMNA (0.78) NPC1L3MBTL1NPSR1ALDH1A1USP2
SCHEMBL29437184 0.84 NPC1 (0.61) NPC1L3MBTL1NPSR1ALDH1A1USP2
SCHEMBL11626565 0.84 NPC1 (0.81) MEN1KMT2ANPC1L3MBTL1NPSR1
SCHEMBL11628250 0.84 NPSR1 (0.67) KMT2ANPC1L3MBTL1NPSR1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260125367-A1 CANCER TREATMENTS TARGETING CANCER STEM CELLS REMEDY PLAN, INC. (US) 2026-05-07 — — US disclosed
US-12522587-B2 Cancer treatments targeting cancer stem cells REMEDY PLAN, INC. (US) 2026-01-13 — — US disclosed
US-20230080054-A1 INHIBITORS OF ANOCTAMIN 6 PROTEIN AND USES THEREOF ILDONG PHARMACEUTICAL CO., LTD. (KR) 2023-03-16 — — US disclosed
US-20220324842-A1 CANCER TREATMENTS TARGETING CANCER STEM CELLS REMEDY PLAN, INC. (US) 2022-10-13 — — US disclosed
EP-3787612-A1 CANCER TREATMENTS TARGETING CANCER STEM CELLS Remedy Plan, Inc. (US) 2021-03-10 — — EP disclosed
CN-112312899-A Cancer therapy targeting cancer stem cells 治疗方案股份有限公司 2021-02-02 — — CN disclosed
EP-1763509-B1 ALPHA-HELICAL MIMETICS WALTER & ELIZA HALL INST MEDICAL RES (AU) 2018-02-21 — — EP disclosed
US-7956216-B2 Benzoyl urea derivatives mimicing BH3-only proteins, able to interact with a Bcl-2 protein THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) 2011-06-07 — — US disclosed
US-20080153802-A1 Alpha-helical mimetics THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) 2008-06-26 — — US disclosed
EP-1763509-A1 ALPHA-HELICAL MIMETICS THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) 2007-03-21 — — EP disclosed
WO-2006002474-A1 ALPHA-HELICAL MIMETICS THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH (AU) 2006-01-12 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230080054-A1 INHIBITORS OF ANOCTAMIN 6 PROTEIN AND USES THEREOF ANO1, ANO2, CACYBP MEN1 1152/4885KMT2A 4212/4885NPC1 2582/4885
US-20080153802-A1 Alpha-helical mimetics BID, BAX, BAD MEN1 2219/4885KMT2A 2959/4885NPC1 3792/4885
US-20260125367-A1 CANCER TREATMENTS TARGETING CANCER STEM CELLS MCL1, MALT1, BCL6 MEN1 1108/4885KMT2A 1185/4885NPC1 1448/4885
US-20220324842-A1 CANCER TREATMENTS TARGETING CANCER STEM CELLS MCL1, CD47, GLI1 MEN1 279/4885KMT2A 450/4885NPC1 3770/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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