Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR2 | P21452 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.39 |
| ▸ | CACNB1 | Q02641 | 2/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | GBA1 | P04062 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | NAMPT | P43490 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18909105 | 0.84 | TACR2 (0.49) | TACR2ALOX15TSHRHSD17B10HRH3 | |
| SCHEMBL3602019 | 0.81 | TACR2 (0.49) | TACR2ALOX15TSHRHSD17B10HRH3 | |
| SCHEMBL22030492 | 0.80 | TACR2 (0.46) | TACR2ALOX15TSHRHSD17B10HRH3 | |
| SCHEMBL24585267 | 0.79 | TACR2 (0.46) | TACR2ALOX15TSHRHSD17B10HRH3 | |
| SCHEMBL2262931 | 0.76 | L3MBTL1 (0.61) | ALOX15TSHRHSD17B10L3MBTL1LMNA | |
| SCHEMBL18909453 | 0.74 | ALOX15 (0.55) | ALOX15TSHRHSD17B10L3MBTL1CACNA2D1 | |
| SCHEMBL26065145 | 0.73 | USP2 (0.58) | L3MBTL1KDM4ELMNARAB9AALDH1A1 | |
| SCHEMBL9275712 | 0.72 | ALDH1A1 (0.48) | ALOX15TSHRHSD17B10L3MBTL1KDM4E | |
| SCHEMBL19275281 | 0.71 | THRB (0.50) | TACR2ALOX15TSHRHSD17B10L3MBTL1 | |
| SCHEMBL18909230 | 0.71 | THRB (0.53) | ALOX15TSHRHSD17B10THRBKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017140825-A1 | THERAPEUTIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2017-08-24 | — | — | WO | disclosed |