Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA4 | P22748 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19876963 | 0.95 | CA2 (0.39) | ADRA1DCA2LTB4RMEN1KMT2A | |
| SCHEMBL27978633 | 0.81 | ADRA1D (0.36) | ADRA1DCA2 | |
| SCHEMBL22260444 | 0.77 | NR1I2 (0.39) | ADRA1DCA2HTTMEN1KMT2A | |
| SCHEMBL27610043 | 0.70 | ALOX5 (0.40) | ADRA1DLTB4RALDH1A1 | |
| SCHEMBL27173455 | 0.69 | ALOX5 (0.36) | ADRA1DGLATSHRHTTL3MBTL1 | |
| SCHEMBL27205077 | 0.69 | ALOX5 (0.36) | ADRA1DGLATSHRHTTL3MBTL1 | |
| SCHEMBL27688660 | 0.68 | ADRA1D (0.42) | ADRA1DALDH1A1NPC1POLBMAPT | |
| SCHEMBL26469606 | 0.68 | TSHR (0.42) | ADRA1DCA2GLATSHRHTT | |
| SCHEMBL155103 | 0.68 | TSHR (0.37) | ADRA1DTSHRHTTL3MBTL1MEN1 | |
| SCHEMBL7276887 | 0.67 | NPC1 (0.50) | GLATSHRHTTL3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017140274-A1 | TRICYCLIC COMPOUND SERVING AS IMMUNOMODULATOR | 正大天晴药业集团股份有限公司 | 2017-08-24 | — | — | WO | disclosed |