Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD2 | P25440 | 1/20 | 0.45 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19280531 | 0.81 | HDAC1 (0.45) | BRD2HSD11B1ALDH1A1 | |
| SCHEMBL974217 | 0.76 | HSD11B1 (0.44) | HSD11B1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL20899628 | 0.76 | BRD4 (0.49) | ALDH1A1MEN1KMT2ATP53MAPT | |
| SCHEMBL21986361 | 0.75 | BRD2 (0.46) | BRD2HSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL14339392 | 0.75 | ALDH1A1 (0.46) | BRD2HSD11B1ALDH1A1MEN1KMT2A | |
| SCHEMBL8513844 | 0.72 | HSD11B1 (0.54) | HSD11B1ALDH1A1SMN1; SMN2POLB | |
| SCHEMBL30910104 | 0.72 | KMT2A (0.42) | HSD11B1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL26089819 | 0.72 | KMT2A (0.42) | HSD11B1ALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL21805774 | 0.71 | P2RX7 (0.49) | HSD11B1ALDH1A1MEN1KMT2APRMT1 | |
| SCHEMBL1861484 | 0.71 | HSD11B1 (0.52) | HSD11B1TP53MAPTPOLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2017-12-14 | — | — | US | disclosed |
| EP-3209664-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS AS PI3K INHIBITORS | Bristol-Myers Squibb Company (US) | 2017-08-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170355707-A1 | BICYCLIC HETEROARYL AMINE COMPOUNDS | PIK3R3, JAK2, JAK3 | BRD2 59/4885HSD11B1 2685/4885ALDH1A1 3131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.