Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19281126 | 0.88 | KMT2A (0.48) | TRPM8KMT2AMEN1NPSR1SIGMAR1 | |
| SCHEMBL467592 | 0.84 | SIGMAR1 (0.64) | KMT2AMEN1NPSR1SIGMAR1 | |
| SCHEMBL19281133 | 0.81 | KMT2A (0.54) | KMT2AMEN1NPSR1SIGMAR1ALDH1A1 | |
| SCHEMBL19281135 | 0.81 | HSD11B1 (0.64) | KMT2AMEN1NPSR1SIGMAR1ALDH1A1 | |
| SCHEMBL12017853 | 0.81 | SIGMAR1 (0.69) | TRPM8SIGMAR1DRD2 | |
| SCHEMBL27095298 | 0.79 | KMT2A (0.48) | TRPM8KMT2AMEN1NPSR1SIGMAR1 | |
| SCHEMBL349554 | 0.77 | HRH3 (0.48) | KMT2AMEN1NPSR1NPC1RAB9A | |
| SCHEMBL349555 | 0.77 | HRH3 (0.48) | KMT2AMEN1NPSR1NPC1RAB9A | |
| SCHEMBL16496527 | 0.76 | KMT2A (0.51) | KMT2AMEN1NPSR1SIGMAR1NPC1 | |
| SCHEMBL31398580 | 0.75 | HSD11B1 (0.60) | KMT2ASIGMAR1ALDH1A1KDM4ERORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2675812-B1 | CHROMAN - SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2017-08-30 | — | — | EP | disclosed |