Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.35 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.35 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.35 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | RHEB | Q15382 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | TTK | P33981 | 1/20 | 0.32 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16382998 | 0.85 | LTA4H (0.46) | LTA4HCHRNA7CHRNA10CHRNA9KCNJ1 | |
| SCHEMBL16383003 | 0.72 | HPGDS (0.43) | LTA4HCHRNA7CHRNA10CHRNA9P2RX7 | |
| SCHEMBL3054443 | 0.69 | LTA4H (0.55) | LTA4HCHRNA7CHRNA10CHRNA9HPGDS | |
| SCHEMBL8239613 | 0.68 | LTA4H (0.50) | LTA4HCHRNA7CHRNA10CHRNA9KCNJ1 | |
| SCHEMBL10366022 | 0.68 | LTA4H (0.50) | LTA4HCHRNA7CHRNA10CHRNA9KCNJ1 | |
| SCHEMBL722557 | 0.67 | LTA4H (0.64) | LTA4HCHRNA7CHRNA10CHRNA9KCNJ1 | |
| SCHEMBL17254244 | 0.66 | KCNJ1 (0.49) | LTA4HCHRNA7CHRNA10CHRNA9KCNJ1 | |
| SCHEMBL3628598 | 0.66 | LTA4H (0.47) | LTA4HCHRNA7CHRNA10CHRNA9KCNJ1 | |
| SCHEMBL28362996 | 0.65 | LTA4H (0.62) | LTA4HCHRNA7CHRNA10CHRNA9KCNJ1 | |
| SCHEMBL28320605 | 0.65 | LTA4H (0.62) | LTA4HCHRNA7CHRNA10CHRNA9KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9745331-B2 | Therapeutic bisphosphonates | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2017-08-29 | — | — | US | disclosed |