Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 6/20 | 0.38 |
| ▸ | EDNRB | P24530 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | BACE2 | Q9Y5Z0 | 3/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.35 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.35 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.34 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12648428 | 0.83 | NOTUM (0.50) | HPGDSCYP3A4LTA4HMAPK1HCRTR1 | |
| SCHEMBL25488454 | 0.82 | MAPK1 (0.43) | HPGDSCYP3A4LTA4HEDNRAEDNRB | |
| SCHEMBL16382998 | 0.81 | LTA4H (0.46) | HPGDSLTA4HEDNRAEDNRBCHRNA7 | |
| SCHEMBL1804513 | 0.80 | PRKCI (0.53) | HPGDSCYP3A4LTA4HMAPK1HCRTR1 | |
| SCHEMBL28164766 | 0.80 | HPGDS (0.46) | HPGDSCYP3A4LTA4HHCRTR1HCRTR2 | |
| SCHEMBL9454674 | 0.80 | HPGDS (0.46) | HPGDSBACE1CYP3A4LTA4HEDNRA | |
| SCHEMBL9863754 | 0.80 | HPGDS (0.46) | HPGDSBACE1CYP3A4LTA4HEDNRA | |
| SCHEMBL14983820 | 0.79 | HPGDS (0.43) | HPGDSBACE1CYP3A4LTA4HEDNRA | |
| SCHEMBL9507339 | 0.78 | HPGDS (0.53) | HPGDSCYP3A4LTA4HHCRTR1HCRTR2 | |
| SCHEMBL3964365 | 0.78 | HPGDS (0.58) | HPGDSBACE1LTA4HBACE2NOTUM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9416149-B2 | Methods to modulate Rac1 import and to treat pulmonary fibrosis | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2016-08-16 | — | — | US | disclosed |
| US-20150005261-A1 | METHODS TO MODULATE RAC1 IMPORT AND TO TREAT PULMONARY FIBROSIS | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2015-01-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150005261-A1 | METHODS TO MODULATE RAC1 IMPORT AND TO TREAT PULMONARY FIBROSIS | RHOT2, RHOA, RAC1 | HPGDS 923/4885BACE1 4486/4885CYP3A4 4668/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.