Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 1/20 | 0.41 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL2347792 | 0.84 | HDAC4 (0.36) | SMN1; SMN2ALDH1A1 | |
| Iodide SCHEMBL2347798 | 0.84 | HDAC4 (0.36) | SMN1; SMN2ALDH1A1 | |
| Iodide SCHEMBL3822941 | 0.83 | STING1 (0.39) | STING1TSHRALDH1A1 | |
| SCHEMBL29843820 | 0.82 | HDAC4 (0.37) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL29843930 | 0.82 | STING1 (0.40) | STING1TSHRALDH1A1 | |
| SCHEMBL28283765 | 0.75 | HDAC4 (0.43) | TSHRKDM4EALDH1A1 | |
| SCHEMBL17786071 | 0.71 | HSP90AA1 (0.46) | HTR3AHSP90AA1RAB9ANPC1LMNA | |
| SCHEMBL18324318 | 0.69 | CCR1 (0.46) | AKR1C3RAB9ANPC1LMNAHPGD | |
| SCHEMBL6024423 | 0.67 | HSP90AA1 (0.46) | STING1AKR1C3HSP90AA1RAB9ALMNA | |
| SCHEMBL20071959 | 0.67 | HSP90AA1 (0.40) | HTR3AHSP90AA1RAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7956192-B2 | Carbene containing metal complexes as OLEDs | THE UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2011-06-07 | — | — | US | disclosed |
| US-20090302754-A1 | CARBENE CONTAINING METAL COMPLEXES AS OLEDS | TSAI JUI-YI | 2009-12-10 | — | — | US | disclosed |
| US-7598388-B2 | Can stabily emit light with various spectra, including high energy blue spectra; tris(1-(2'-(9',9'-dimethyl)fluorenyl)-3-methyl-imidazolin-2-ylidene-C,C3') iridium(III); organic light emitting devices; combining L, a carbene ligand precursor, with an organic solvent at about 175 degrees C. | THE UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-10-06 | — | — | US | disclosed |
| US-7534505-B2 | Organometallic compounds for use in electroluminescent devices | THE UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2009-05-19 | — | — | US | disclosed |
| WO-2005113704-A2 | LUMINESCENT COMPOUNDS WITH CARBENE LIGANDS | THE UNIVERSITY OF SOUTHERN CALIFORNIA (US) | 2005-12-01 | — | — | WO | disclosed |
| US-20050258742-A1 | Carbene containing metal complexes as OLEDs | UNIVERSAL DISPLAY CORPORATION | 2005-11-24 | — | — | US | disclosed |
| US-20050260448-A1 | Novel organometallic compounds for use in electroluminescent devices | UNIVERSAL DISPLAY CORPORATION | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090302754-A1 | CARBENE CONTAINING METAL COMPLEXES AS OLEDS | OPRD1, OGFRL1, OCIAD1 | HTR3A 2782/4885STING1 3225/4885AKR1C3 256/4885 |
| US-20050258742-A1 | Carbene containing metal complexes as OLEDs | OPRD1, OGFRL1, OCIAD1 | HTR3A 2782/4885STING1 3225/4885AKR1C3 256/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.