Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.34 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.34 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.34 |
| ▸ | ALB | P02768 | 1/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.34 |
| ▸ | RARB | P10826 | 1/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.34 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22343670 | 0.84 | KDM4E (0.40) | KDM4EL3MBTL1ESR1CPB2BTK | |
| SCHEMBL15007 | 0.78 | KDM4E (0.61) | KDM4EL3MBTL1BTK | |
| SCHEMBL19728335 | 0.76 | GABRA1 (0.33) | GABRA1GABRB2 | |
| SCHEMBL13044959 | 0.76 | CYP11B1 (0.42) | GABRA1GABRB2PTGS1PTGS2LMNA | |
| SCHEMBL25636541 | 0.75 | CCR1 (0.41) | L3MBTL1GABRA1GABRB2PTGS1PTGS2 | |
| SCHEMBL19735731 | 0.74 | KDM4E (0.45) | KDM4EL3MBTL1LMNANFKB1TSHR | |
| SCHEMBL14406088 | 0.74 | ESR1 (0.47) | GABRA1GABRB2PTGS1PTGS2LMNA | |
| SCHEMBL19728333 | 0.74 | GABRA1 (0.37) | KDM4EGABRA1GABRB2MAPK1BTK | |
| SCHEMBL14878746 | 0.74 | KDM4E (0.39) | KDM4EL3MBTL1BTK | |
| SCHEMBL11124858 | 0.74 | ALDH1A1 (0.41) | KDM4EL3MBTL1GABRA1GABRB2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11229639-B2 | Camptothecin derivatives | IMMUNOGEN, INC. (US) | 2022-01-25 | — | — | US | disclosed |
| US-11053197-B2 | Carbazole derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-07-06 | — | — | US | disclosed |
| US-20210077482-A1 | CAMPTOTHECIN DERIVATIVES | IMMUNOGEN, INC. | 2021-03-18 | — | — | US | disclosed |
| US-20200255377-A1 | CARBAZOLE DERIVATIVES | Organization Name: BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-08-13 | — | — | US | disclosed |
| US-10676434-B2 | Carbazole derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-06-09 | — | — | US | disclosed |
| US-20190225583-A1 | CARBAZOLE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2019-07-25 | — | — | US | disclosed |
| US-10266491-B2 | Carbazole derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-04-23 | — | — | US | disclosed |
| US-20170362176-A1 | CARBAZOLE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-12-21 | — | — | US | disclosed |
| US-20170362176-A1 | CARBAZOLE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-12-21 | — | — | US | disclosed |
| EP-2675812-B1 | CHROMAN - SPIROCYCLIC PIPERIDINE AMIDES AS MODULATORS OF ION CHANNELS | VERTEX PHARMA (US) | 2017-08-30 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10266491-B2 | Carbazole derivatives | BTK, SYK, JAK2 | KDM4E 1490/4885L3MBTL1 1355/4885GABRA1 1512/4885 |
| US-10676434-B2 | Carbazole derivatives | BTK, SYK, JAK2 | KDM4E 1307/4885L3MBTL1 1459/4885GABRA1 1533/4885 |
| US-20210077482-A1 | CAMPTOTHECIN DERIVATIVES | TOP2A, TOP2B, PCNA | KDM4E 4588/4885L3MBTL1 1452/4885GABRA1 4351/4885 |
| US-20170362176-A1 | CARBAZOLE DERIVATIVES | BTK, SYK, JAK2 | KDM4E 1490/4885L3MBTL1 1355/4885GABRA1 1512/4885 |
| US-11053197-B2 | Carbazole derivatives | BTK, SYK, JAK2 | KDM4E 1307/4885L3MBTL1 1459/4885GABRA1 1533/4885 |
| US-20190225583-A1 | CARBAZOLE DERIVATIVES | BTK, SYK, JAK2 | KDM4E 1307/4885L3MBTL1 1459/4885GABRA1 1533/4885 |
| US-11229639-B2 | Camptothecin derivatives | TOP2A, TOP2B, PCNA | KDM4E 4588/4885L3MBTL1 1452/4885GABRA1 4351/4885 |
| US-20200255377-A1 | CARBAZOLE DERIVATIVES | BTK, SYK, JAK2 | KDM4E 1307/4885L3MBTL1 1459/4885GABRA1 1533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.