Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.33 |
| ▸ | CCNK | O75909 | 1/20 | 0.31 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24331539 | 0.79 | GABRA1 (0.33) | GABRA1GABRB2 | |
| SCHEMBL19289596 | 0.76 | KDM4E (0.40) | GABRA1GABRB2 | |
| SCHEMBL21508909 | 0.76 | KDM4E (0.37) | — | |
| SCHEMBL18858528 | 0.73 | GABRA1 (0.38) | GABRA1GABRB2 | |
| SCHEMBL2625522 | 0.73 | GABRA1 (0.38) | GABRA1GABRB2 | |
| SCHEMBL13599964 | 0.71 | P2RX3 (0.41) | GABRA1GABRB2 | |
| SCHEMBL15858739 | 0.71 | GABRA1 (0.36) | GABRA1GABRB2 | |
| SCHEMBL18856278 | 0.71 | GABRA1 (0.36) | GABRA1GABRB2 | |
| SCHEMBL25802303 | 0.71 | LMNA (0.31) | — | |
| SCHEMBL25510587 | 0.70 | GABRA1 (0.35) | GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11053197-B2 | Carbazole derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-07-06 | — | — | US | disclosed |
| US-20200255377-A1 | CARBAZOLE DERIVATIVES | Organization Name: BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-08-13 | — | — | US | disclosed |
| US-10676434-B2 | Carbazole derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2020-06-09 | — | — | US | disclosed |
| US-20190225583-A1 | CARBAZOLE DERIVATIVES | BRISTOL MYERS SQUIBB CO (US) | 2019-07-25 | — | — | US | disclosed |
| US-10266491-B2 | Carbazole derivatives | BRISTOL-MYERS SQUIBB COMPANY (US) | 2019-04-23 | — | — | US | disclosed |
| US-20170362176-A1 | CARBAZOLE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-12-21 | — | — | US | disclosed |
| US-20170362176-A1 | CARBAZOLE DERIVATIVES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2017-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10266491-B2 | Carbazole derivatives | BTK, SYK, JAK2 | GABRA1 1512/4885GABRB2 1533/4885CCNK 275/4885 |
| US-10676434-B2 | Carbazole derivatives | BTK, SYK, JAK2 | GABRA1 1533/4885GABRB2 1554/4885CCNK 300/4885 |
| US-20170362176-A1 | CARBAZOLE DERIVATIVES | BTK, SYK, JAK2 | GABRA1 1512/4885GABRB2 1533/4885CCNK 275/4885 |
| US-11053197-B2 | Carbazole derivatives | BTK, SYK, JAK2 | GABRA1 1533/4885GABRB2 1554/4885CCNK 300/4885 |
| US-20190225583-A1 | CARBAZOLE DERIVATIVES | BTK, SYK, JAK2 | GABRA1 1533/4885GABRB2 1554/4885CCNK 300/4885 |
| US-20200255377-A1 | CARBAZOLE DERIVATIVES | BTK, SYK, JAK2 | GABRA1 1533/4885GABRB2 1554/4885CCNK 300/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.