Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | PNMT | P11086 | 1/20 | 0.47 |
| ▸ | HTR6 | P50406 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27719897 | 0.80 | HTR2C (0.47) | HTR2CHTR2BPNMTHTR6ALDH1A1 | |
| SCHEMBL30558354 | 0.80 | HTR6 (0.48) | HTR2CHTR2BPNMTHTR6ALDH1A1 | |
| SCHEMBL14350330 | 0.80 | HTR6 (0.48) | HTR2CHTR2BPNMTHTR6ALDH1A1 | |
| SCHEMBL314648 | 0.79 | HTR2C (0.46) | HTR2CHTR2BPNMTHTR6ALDH1A1 | |
| SCHEMBL315527 | 0.75 | HTR2C (0.54) | HTR2CHTR2BPNMTHTR6ALDH1A1 | |
| SCHEMBL316166 | 0.73 | GRM5 (0.54) | HTR2CHTR2BPNMTHTR6ALDH1A1 | |
| SCHEMBL13513169 | 0.72 | HTR2C (0.50) | HTR2CHTR2BPNMTHTR6ALDH1A1 | |
| SCHEMBL3933110 | 0.70 | HTR2C (0.51) | HTR2CHTR2BPNMTHTR6ALDH1A1 | |
| SCHEMBL31375435 | 0.69 | CES1 (0.43) | MAPTSMN1; SMN2TSHR | |
| SCHEMBL6244296 | 0.69 | CES1 (0.43) | MAPTSMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170247321-A1 | TETRALIN AND INDANE DERIVATIVES AND USES THEREOF | ROCHE PALO ALTO LLC (US) | 2017-08-31 | — | — | US | disclosed |
| US-20170247321-A1 | TETRALIN AND INDANE DERIVATIVES AND USES THEREOF | ROCHE PALO ALTO LLC (US) | 2017-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170247321-A1 | TETRALIN AND INDANE DERIVATIVES AND USES THEREOF | ERLIN1, INSRR, PSEN1 | HTR2C 1874/4885HTR2B 1918/4885PNMT 1588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.