Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.51 |
| ▸ | HTR2B | P41595 | 3/20 | 0.51 |
| ▸ | PNMT | P11086 | 1/20 | 0.49 |
| ▸ | HTR6 | P50406 | 11/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28316115 | 0.86 | HTR2C (0.52) | HTR2CHTR2BPNMTHTR6 | |
| SCHEMBL13447890 | 0.79 | CA1 (0.44) | ALDH1A1SMN1; SMN2LMNATSHR | |
| SCHEMBL1706010 | 0.71 | HTR2C (0.73) | HTR2CHTR2BPNMTHTR6ALDH1A1 | |
| SCHEMBL3420195 | 0.71 | PARP10 (0.39) | ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL19296352 | 0.70 | HTR2C (0.49) | HTR2CHTR2BPNMTHTR6ALDH1A1 | |
| SCHEMBL2525091 | 0.69 | FFAR4 (0.31) | — | |
| SCHEMBL5051390 | 0.69 | HTR6 (0.93) | HTR6ALDH1A1POLBMAPTSMN1; SMN2 | |
| SCHEMBL17858418 | 0.68 | ALDH1A1 (0.52) | ALDH1A1POLBMAPTTSHR | |
| SCHEMBL24036626 | 0.68 | ALDH1A1 (0.44) | HTR2BALDH1A1MAPTLMNATHRB | |
| SCHEMBL315527 | 0.68 | HTR2C (0.54) | HTR2CHTR2BPNMTHTR6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041079-A1 | ARYLSULFONYL NAPHTHALENE DERIVATIVES AND USES THEREOF | F. Hoffmann-Roche AG (CH) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007147763-A1 | ARYLSULFONYL NAPHTHALENE DERIVATIVES AND USES THEREOF | F. HOFFMANN-LA ROCHE AG (CH) | 2007-12-27 | — | — | WO | disclosed |