Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 5/20 | 0.41 |
| ▸ | POLB | P06746 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1930920 | 0.87 | ACHE (0.38) | MAPK1HSD17B10HPGDPOLBSMN1; SMN2 | |
| SCHEMBL1929911 | 0.86 | MAPK1 (0.50) | MAPK1HSD17B10HPGDPOLBSMN1; SMN2 | |
| SCHEMBL1929830 | 0.83 | L3MBTL1 (0.39) | MAPK1HSD17B10HPGDSMN1; SMN2USP2 | |
| SCHEMBL1930919 | 0.79 | L3MBTL1 (0.35) | MAPK1HSD17B10HPGDSMN1; SMN2USP2 | |
| SCHEMBL1930363 | 0.76 | NPC1 (0.50) | MAPK1HSD17B10HPGDPOLBSMN1; SMN2 | |
| SCHEMBL1930206 | 0.75 | L3MBTL1 (0.48) | MAPK1HSD17B10HPGDSMN1; SMN2USP2 | |
| SCHEMBL1930375 | 0.75 | ALDH1A1 (0.49) | HSD17B10HPGDPOLBSMN1; SMN2TSHR | |
| SCHEMBL1929051 | 0.71 | L3MBTL1 (0.51) | MAPK1HSD17B10HPGDPOLBSMN1; SMN2 | |
| SCHEMBL3861840 | 0.70 | L3MBTL1 (0.41) | MAPK1HSD17B10HPGDSMN1; SMN2USP2 | |
| SCHEMBL1930606 | 0.70 | GUSB (0.42) | HSD17B10HPGDSMN1; SMN2L3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7541372-B2 | Aryl-isoxazolo-4-yl-oxadiazole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-06-02 | — | — | US | claimed |