Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KLKB1 | P03952 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.46 |
| ▸ | KLK1 | P06870 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17229366 | 0.89 | KLKB1 (0.51) | HSD17B10LMNAALDH1A1MAPTHTT | |
| SCHEMBL27364232 | 0.89 | KLKB1 (0.53) | HSD17B10LMNAALDH1A1MAPTHTT | |
| SCHEMBL752774 | 0.88 | LMNA (0.61) | HSD17B10LMNAALDH1A1MAPTHTT | |
| SCHEMBL27286142 | 0.88 | HSD17B10 (0.68) | HSD17B10LMNAALDH1A1MAPTHTT | |
| SCHEMBL13692389 | 0.87 | L3MBTL1 (0.54) | HSD17B10LMNAALDH1A1MAPTHTT | |
| SCHEMBL27259482 | 0.86 | KLKB1 (0.51) | HSD17B10LMNAALDH1A1MAPTHTT | |
| SCHEMBL19299982 | 0.85 | HSD17B10 (0.65) | HSD17B10LMNAALDH1A1MAPTKLKB1 | |
| SCHEMBL17454410 | 0.85 | L3MBTL1 (0.58) | HSD17B10LMNAALDH1A1MAPTHTT | |
| SCHEMBL19300042 | 0.84 | HSD17B10 (0.49) | HSD17B10LMNAALDH1A1MAPTHTT | |
| SCHEMBL27286146 | 0.84 | MAOB (0.47) | HSD17B10LMNAALDH1A1MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017144995-A1 | PYRAZOLO[1,5-A]PYRAZIN-4-YL DERIVATIVES AS JAK-INHIBITORS | PFIZER INC. (US) | 2017-08-31 | — | — | WO | disclosed |