Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | USP2 | O75604 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | BLM | P54132 | 1/20 | 0.51 |
| ▸ | SLC12A2 | P55011 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | AQP1 | P29972 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.37 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11121179 | 0.89 | KDM4E (0.51) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| SCHEMBL18993670 | 0.82 | KDM4E (0.51) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| SCHEMBL11538214 | 0.79 | KDM4E (0.58) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| Hydrochloric Acid SCHEMBL11539001 | 0.78 | KDM4E (0.57) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| SCHEMBL18993671 | 0.77 | KDM4E (0.51) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| SCHEMBL18993669 | 0.77 | KDM4E (0.51) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| SCHEMBL11540082 | 0.77 | KDM4E (0.56) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| Hydrochloric Acid SCHEMBL11540442 | 0.76 | KDM4E (0.56) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| SCHEMBL11543578 | 0.76 | KDM4E (0.54) | KDM4EUSP2ALDH1A1LMNAHPGD | |
| SCHEMBL11540200 | 0.76 | KDM4E (0.54) | KDM4EUSP2ALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170246131-A1 | BUMETANIDE ANALOGS, COMPOSITIONS, AND METHODS OF USE | NEUROPRO THERAPEUTICS INC (US) | 2017-08-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170246131-A1 | BUMETANIDE ANALOGS, COMPOSITIONS, AND METHODS OF USE | SLC6A1, SLC6A13, SLC6A11 | KDM4E 2228/4885USP2 3353/4885ALDH1A1 889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.