Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.63 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.63 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.63 |
| ▸ | PRKCA | P17252 | 1/20 | 0.63 |
| ▸ | LPAR3 | Q9UBY5 | 6/20 | 0.60 |
| ▸ | LPAR1 | Q92633 | 3/20 | 0.60 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | LPAR2 | Q9HBW0 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | GMNN | O75496 | 1/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19300938 | 0.89 | ALDH1A1 (0.51) | LMNAALDH1A1PRKCEPRKCQPRKCD | |
| SCHEMBL22647858 | 0.89 | ALDH1A1 (0.51) | LMNAALDH1A1PRKCEPRKCQPRKCD | |
| SCHEMBL345928 | 0.87 | ALDH1A1 (0.84) | LMNAALDH1A1PRKCEPRKCQPRKCD | |
| SCHEMBL19285724 | 0.87 | ALDH1A1 (0.84) | LMNAALDH1A1PRKCEPRKCQPRKCD | |
| SCHEMBL11782897 | 0.87 | ALDH1A1 (0.84) | LMNAALDH1A1PRKCEPRKCQPRKCD | |
| SCHEMBL25272152 | 0.87 | ALDH1A1 (0.84) | LMNAALDH1A1PRKCEPRKCQPRKCD | |
| SCHEMBL6014563 | 0.87 | ALDH1A1 (0.84) | LMNAALDH1A1PRKCEPRKCQPRKCD | |
| SCHEMBL21409342 | 0.87 | ALDH1A1 (0.84) | LMNAALDH1A1PRKCEPRKCQPRKCD | |
| SCHEMBL21472154 | 0.87 | ALDH1A1 (0.84) | LMNAALDH1A1PRKCEPRKCQPRKCD | |
| SCHEMBL4862128 | 0.87 | ALDH1A1 (0.84) | LMNAALDH1A1PRKCEPRKCQPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20200352894-A1 | COMBINATION THERAPY | RA CAPITAL HEALTHCARE FUND, L.P. | 2020-11-12 | — | — | US | disclosed |
| US-10786476-B2 | Combination therapy | IMBRIA PHARMACEUTICALS, INC. (US) | 2020-09-29 | — | — | US | disclosed |
| US-20190314319-A1 | COMBINATION THERAPY | IMBRIA PHARMACEUTICALS, INC. | 2019-10-17 | — | — | US | disclosed |
| WO-2017147220-A1 | COMBINATION THERAPY | CARNOT, LLC (US) | 2017-08-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200352894-A1 | COMBINATION THERAPY | PC, ABAT, CKMT1A; CKMT1B | LMNA 2717/4885ALDH1A1 286/4885PRKCE 1474/4885 |
| US-20190314319-A1 | COMBINATION THERAPY | PC, ABAT, CKMT1A; CKMT1B | LMNA 2717/4885ALDH1A1 286/4885PRKCE 1474/4885 |
| US-10786476-B2 | Combination therapy | PC, ABAT, CKMT1A; CKMT1B | LMNA 2717/4885ALDH1A1 286/4885PRKCE 1474/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.