Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 7/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 2/20 | 0.36 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.35 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25946364 | 0.89 | MERTK (0.39) | — | |
| SCHEMBL17054293 | 0.81 | EPHX2 (0.37) | ALDH1A1 | |
| SCHEMBL31532323 | 0.81 | TLR9 (0.32) | — | |
| SCHEMBL15483107 | 0.79 | CRHR1 (0.52) | CRHR1ALDH1A1LMNAPOLB | |
| SCHEMBL25586337 | 0.79 | GRM2 (0.40) | L3MBTL1MAPTALDH1A1LMNAPOLB | |
| SCHEMBL23566750 | 0.78 | CRHR1 (0.40) | CRHR1L3MBTL1MAPTALDH1A1LMNA | |
| SCHEMBL24884369 | 0.76 | MPO (0.40) | CRHR1L3MBTL1MAPTALDH1A1LMNA | |
| SCHEMBL19301624 | 0.76 | GRM2 (0.41) | CRHR1L3MBTL1MAPTALDH1A1LMNA | |
| SCHEMBL19659498 | 0.75 | CNR1 (0.41) | — | |
| SCHEMBL23213634 | 0.75 | LMNA (0.60) | L3MBTL1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017147102-A1 | HETEROARYL INHIBITORS OF PAD4 | PADLOCK THERAPEUTICS, INC. (US) | 2017-08-31 | — | — | WO | disclosed |