Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | KDM4C | Q9H3R0 | 6/20 | 0.45 |
| ▸ | KDM5A | P29375 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | ASPH | Q12797 | 2/20 | 0.41 |
| ▸ | KDM8 | Q8N371 | 2/20 | 0.41 |
| ▸ | KDM4A | O75164 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.37 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.37 |
| ▸ | KDM5B | Q9UGL1 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4954467 | 0.82 | LMNA (0.50) | SMN1; SMN2LMNAKDM4CKDM5AKDM4E | |
| SCHEMBL29593855 | 0.80 | ATR (0.50) | SMN1; SMN2LMNAKDM4CKDM4EL3MBTL1 | |
| SCHEMBL15351124 | 0.80 | ATR (0.50) | SMN1; SMN2LMNAKDM4CKDM4EL3MBTL1 | |
| SCHEMBL15350459 | 0.78 | CYP4F2 (0.50) | LMNAKDM4EL3MBTL1TSHRCASP1 | |
| SCHEMBL1577580 | 0.77 | KDM5B (0.46) | SMN1; SMN2LMNAKDM4CKDM5AKDM4E | |
| SCHEMBL31068139 | 0.76 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAKDM4CKDM5AKDM4E | |
| SCHEMBL18030726 | 0.76 | SMN1; SMN2 (0.55) | SMN1; SMN2LMNAKDM4CKDM5AKDM4E | |
| SCHEMBL83616 | 0.75 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAKDM4CKDM5AKDM4E | |
| SCHEMBL29486104 | 0.75 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAKDM4CKDM5AKDM4E | |
| SCHEMBL21273627 | 0.74 | KDM4E (0.41) | SMN1; SMN2LMNAKDM4CKDM5AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2841435-B1 | PYRROLOPYRIDINONE DERIVATIVES AS TTX-S BLOCKERS | RAQUALIA PHARMA INC (JP) | 2017-09-06 | — | — | EP | disclosed |