Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | XBP1 | P17861 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1930672 | 0.81 | NPSR1 (0.57) | BRD4NPSR1KDM4EALDH1A1TSHR | |
| SCHEMBL1930084 | 0.80 | L3MBTL1 (0.67) | BRD4NPSR1KDM4EALDH1A1TSHR | |
| SCHEMBL1930424 | 0.80 | NPSR1 (0.56) | BRD4NPSR1KDM4EALDH1A1TSHR | |
| SCHEMBL1931184 | 0.78 | NPSR1 (0.56) | NPSR1KDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL16493850 | 0.78 | NPSR1 (0.58) | NPSR1KDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL1930071 | 0.77 | NPSR1 (0.63) | BRD4NPSR1KDM4EALDH1A1TSHR | |
| SCHEMBL1930470 | 0.76 | L3MBTL1 (0.60) | NPSR1KDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL1930392 | 0.76 | L3MBTL1 (0.62) | NPSR1KDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL1931147 | 0.76 | L3MBTL1 (0.59) | NPSR1KDM4EALDH1A1TSHRHSD17B10 | |
| SCHEMBL1930141 | 0.76 | NPC1 (0.62) | NPSR1KDM4EALDH1A1TSHRHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1968972-B1 | ARYL-ISOXAZOLO-4-YL-OXADIAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-11-28 | — | — | EP | claimed |
| US-7956074-B2 | Aryl-isoxazolo-4-yl-oxadiazole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-06-07 | — | — | US | claimed |
| US-20090197875-A1 | ARYL-ISOXAZOLO-4-YL-OXADIAZOLE DERIVATIVES | BUETTELMANN BERND | 2009-08-06 | — | — | US | claimed |
| EP-1968972-A1 | ARYL-ISOXAZOLO-4-YL-OXADIAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-09-17 | — | — | EP | claimed |
| US-20070161686-A1 | Aryl-isoxazolo-4-yl-oxadiazole derivatives | HOFFMANN-LA ROCHE INC. | 2007-07-12 | — | — | US | claimed |
| WO-2007071598-A1 | ARYL-ISOXAZOLO-4-YL-OXADIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-28 | — | — | WO | claimed |
| EP-1968972-B1 | ARYL-ISOXAZOLO-4-YL-OXADIAZOLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2012-11-28 | — | — | EP | disclosed |
| US-7956074-B2 | Aryl-isoxazolo-4-yl-oxadiazole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2011-06-07 | — | — | US | disclosed |
| US-20090197875-A1 | ARYL-ISOXAZOLO-4-YL-OXADIAZOLE DERIVATIVES | BUETTELMANN BERND | 2009-08-06 | — | — | US | disclosed |
| US-7541372-B2 | Aryl-isoxazolo-4-yl-oxadiazole derivatives | HOFFMAN-LA ROCHE INC. (US) | 2009-06-02 | — | — | US | disclosed |
| EP-1968972-A1 | ARYL-ISOXAZOLO-4-YL-OXADIAZOLE DERIVATIVES | F. Hoffmann-La Roche AG (CH) | 2008-09-17 | — | — | EP | disclosed |
| US-20070161686-A1 | Aryl-isoxazolo-4-yl-oxadiazole derivatives | HOFFMANN-LA ROCHE INC. | 2007-07-12 | — | — | US | disclosed |
| WO-2007071598-A1 | ARYL-ISOXAZOLO-4-YL-OXADIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090197875-A1 | ARYL-ISOXAZOLO-4-YL-OXADIAZOLE DERIVATIVES | GABRA5, GABRA4, GABRA3 | BRD4 1112/4885NPSR1 190/4885KDM4E 1328/4885 |
| US-20070161686-A1 | Aryl-isoxazolo-4-yl-oxadiazole derivatives | GABRA5, GABRA4, GABRA3 | BRD4 1112/4885NPSR1 190/4885KDM4E 1328/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.