Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.70 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.70 |
| ▸ | PDE4A | P27815 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.36 |
| ▸ | GSR | P00390 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Semustine SCHEMBL4500 | 0.84 | ALDH1A1 (1.00) | SMN1; SMN2ADRA2AALDH1A1PDE4AADRA1A | |
| Semustine SCHEMBL4959160 | 0.84 | ALDH1A1 (1.00) | SMN1; SMN2ADRA2AALDH1A1PDE4AADRA1A | |
| Semustine SCHEMBL28854924 | 0.83 | ALDH1A1 (0.97) | SMN1; SMN2ADRA2AALDH1A1PDE4AADRA1A | |
| Semustine SCHEMBL2350016 | 0.80 | ALDH1A1 (0.92) | SMN1; SMN2ADRA2AALDH1A1PDE4AADRA1A | |
| Semustine SCHEMBL8980108 | 0.74 | ALDH1A1 (0.79) | SMN1; SMN2ADRA2AALDH1A1PDE4AADRA1A | |
| SCHEMBL3341308 | 0.72 | ADRA2A (0.77) | SMN1; SMN2ADRA2AALDH1A1PDE4AADRA1A | |
| SCHEMBL3341311 | 0.72 | ADRA2A (0.77) | SMN1; SMN2ADRA2AALDH1A1PDE4AADRA1A | |
| Lomustine SCHEMBL3995 | 0.72 | ADRA2A (1.00) | SMN1; SMN2ADRA2AALDH1A1PDE4AADRA1A | |
| Lomustine SCHEMBL868328 | 0.72 | ADRA2A (1.00) | SMN1; SMN2ADRA2AALDH1A1PDE4AADRA1A | |
| Lomustine SCHEMBL1831239 | 0.71 | ADRA2A (0.86) | SMN1; SMN2ADRA2AALDH1A1PDE4AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10611761-B2 | Selective EP4 receptor antagonistic substance for treatment of cancer | ASKAT INC. (JP) | 2020-04-07 | — | — | US | disclosed |
| US-20170253595-A1 | SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER | ASKAT INC. (JP) | 2017-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170253595-A1 | SELECTIVE EP4 RECEPTOR ANTAGONISTIC SUBSTANCE FOR TREATMENT OF CANCER | PTGER4, PTGER1, PTGER2 | SMN1; SMN2 4129/4885ADRA2A 236/4885ALDH1A1 1179/4885 |
| US-10611761-B2 | Selective EP4 receptor antagonistic substance for treatment of cancer | PTGER4, PTGER1, PTGER2 | SMN1; SMN2 4123/4885ADRA2A 231/4885ALDH1A1 1131/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.