Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 11/20 | 0.40 |
| ▸ | PCNA | P12004 | 9/20 | 0.40 |
| ▸ | THRA | P10827 | 7/20 | 0.40 |
| ▸ | LMNA | P02545 | 6/20 | 0.40 |
| ▸ | MEN1 | O00255 | 6/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.40 |
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19308104 | 0.90 | THRB (0.45) | THRBPCNATHRALMNAMEN1 | |
| SCHEMBL13949734 | 0.84 | THRB (0.41) | THRBPCNATHRALMNAMEN1 | |
| SCHEMBL13949735 | 0.79 | THRB (0.41) | THRBPCNATHRALMNAMEN1 | |
| SCHEMBL13949736 | 0.79 | THRB (0.64) | THRBPCNATHRALMNAMEN1 | |
| SCHEMBL12584474 | 0.76 | THRB (0.62) | THRBPCNATHRALMNAMEN1 | |
| SCHEMBL12584488 | 0.74 | THRB (0.47) | THRBPCNATHRALMNAMEN1 | |
| SCHEMBL18556479 | 0.73 | THRB (0.58) | THRBPCNATHRALMNAMEN1 | |
| SCHEMBL17612147 | 0.72 | THRB (0.42) | THRBPCNATHRALMNAMEN1 | |
| SCHEMBL12584490 | 0.70 | THRB (0.47) | THRBPCNATHRALMNAMEN1 | |
| SCHEMBL12584374 | 0.69 | ITGB3 (0.44) | THRBPCNATHRALMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9750709-B2 | Nanoparticle and polymer formulations for thyroid hormone analogs, antagonists, and formulations thereof | NANOPHARMACEUTICALS LLC (US) | 2017-09-05 | — | — | US | disclosed |