Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.53 |
| ▸ | HTR7 | P34969 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19317249 | 0.93 | L3MBTL1 (0.63) | L3MBTL1KDM4EGAAPKMSMN1; SMN2 | |
| SCHEMBL19317296 | 0.91 | KDM4E (0.65) | L3MBTL1KDM4EGAAPKMSMN1; SMN2 | |
| SCHEMBL19317330 | 0.89 | KDM4E (0.59) | L3MBTL1KDM4EGAAPKMSMN1; SMN2 | |
| SCHEMBL19321948 | 0.88 | L3MBTL1 (0.61) | L3MBTL1KDM4EGAAPKMSMN1; SMN2 | |
| SCHEMBL19354877 | 0.85 | L3MBTL1 (0.60) | L3MBTL1KDM4EGAAPKMSMN1; SMN2 | |
| SCHEMBL19317247 | 0.83 | KMT2A (0.56) | L3MBTL1KDM4EGAASMN1; SMN2ATM | |
| SCHEMBL19317250 | 0.82 | KMT2A (0.59) | L3MBTL1KDM4ESMN1; SMN2HTR7ALDH1A1 | |
| SCHEMBL19354673 | 0.81 | L3MBTL1 (0.53) | L3MBTL1KDM4EGAAPKMSMN1; SMN2 | |
| SCHEMBL19321935 | 0.81 | L3MBTL1 (0.70) | L3MBTL1KDM4EGAAPKMSMN1; SMN2 | |
| SCHEMBL19354545 | 0.80 | L3MBTL1 (0.84) | L3MBTL1KDM4EGAAPKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10544113-B2 | Thiazolidinone compounds and use thereof | NATIONAL HEALTH RESEARCH INSTITUTE (TW) | 2020-01-28 | — | — | US | disclosed |
| US-20170253569-A1 | THIAZOLIDINONE COMPOUNDS AND USE THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2017-09-07 | — | — | US | disclosed |
| US-20170253569-A1 | THIAZOLIDINONE COMPOUNDS AND USE THEREOF | REGENTS OF THE UNIVERSITY OF MINNESOTA | 2017-09-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10544113-B2 | Thiazolidinone compounds and use thereof | OPRL1, OPRD1, OPRK1 | L3MBTL1 4651/4885KDM4E 3848/4885GAA 1589/4885 |
| US-20170253569-A1 | THIAZOLIDINONE COMPOUNDS AND USE THEREOF | OPRL1, OPRD1, OPRK1 | L3MBTL1 4651/4885KDM4E 3848/4885GAA 1589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.