Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Toluene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | TSHR | P16473 | 2/20 | 0.61 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.61 |
| ▸ | ACHE | P22303 | 1/20 | 0.61 |
| ▸ | ACP3 | P15309 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Toluene SCHEMBL27955550 | 1.00 | LMNA (0.61) | LMNATSHRALOX12ACHEACP3 | |
| Toluene SCHEMBL27988775 | 0.97 | LMNA (0.58) | LMNATSHRALOX12ACHEACP3 | |
| Toluene SCHEMBL695755 | 0.97 | LMNA (0.65) | LMNATSHRALOX12ACHEACP3 | |
| Toluene SCHEMBL28555681 | 0.97 | LMNA (0.65) | LMNATSHRALOX12ACHEACP3 | |
| Toluene SCHEMBL5806354 | 0.97 | LMNA (0.65) | LMNATSHRALOX12ACHEACP3 | |
| Toluene SCHEMBL437383 | 0.97 | LMNA (0.65) | LMNATSHRALOX12ACHEACP3 | |
| Toluene SCHEMBL1011089 | 0.97 | LMNA (0.65) | LMNATSHRALOX12ACHEACP3 | |
| Toluene SCHEMBL10856877 | 0.97 | LMNA (0.65) | LMNATSHRALOX12ACHEACP3 | |
| Toluene SCHEMBL27269290 | 0.97 | LMNA (0.65) | LMNATSHRALOX12ACHEACP3 | |
| Toluene SCHEMBL3630619 | 0.94 | LMNA (0.61) | LMNATSHRALOX12ACHEACP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12215275-B2 | Compositions for enhanced oil recovery | CHAMPIONX LLC | 2025-02-04 | — | — | US | claimed |
| US-20220298408-A1 | COMPOSITIONS FOR ENHANCED OIL RECOVERY | CHAMPIONX LLC | 2022-09-22 | — | — | US | claimed |
| WO-2021035207-A1 | COMPOSITIONS FOR ENHANCED OIL RECOVERY | ECOLAB USA INC. (US) | 2021-02-25 | — | — | WO | claimed |
| US-12215275-B2 | Compositions for enhanced oil recovery | CHAMPIONX LLC | 2025-02-04 | — | — | US | disclosed |
| US-12215275-B2 | Compositions for enhanced oil recovery | CHAMPIONX LLC | 2025-02-04 | — | — | US | disclosed |
| CN-114181091-B | Synthesis process of adamantane triphenylamine | 维思普新材料（苏州）有限公司 | 2024-06-14 | — | — | CN | disclosed |
| US-20220298408-A1 | COMPOSITIONS FOR ENHANCED OIL RECOVERY | CHAMPIONX LLC | 2022-09-22 | — | — | US | disclosed |
| US-20220298408-A1 | COMPOSITIONS FOR ENHANCED OIL RECOVERY | CHAMPIONX LLC | 2022-09-22 | — | — | US | disclosed |
| WO-2021035207-A1 | COMPOSITIONS FOR ENHANCED OIL RECOVERY | ECOLAB USA INC. (US) | 2021-02-25 | — | — | WO | disclosed |
| WO-2021035207-A1 | COMPOSITIONS FOR ENHANCED OIL RECOVERY | ECOLAB USA INC. (US) | 2021-02-25 | — | — | WO | disclosed |
| CN-110407823-A | Organic Light Emitting Diode material | UNIVERSAL DISPLAY CORP | 2019-11-05 | — | — | CN | disclosed |
| CN-104292220-B | Organic Light Emitting Diode material | 环球展览公司 | 2019-08-23 | — | — | CN | disclosed |
| CN-104292220-A | Organic light emitting diode material | UNIVERSAL DISPLAY CORP | 2015-01-21 | — | — | CN | disclosed |
| US-8420354-B2 | Methods to manufacture 1,3-dioxolane nucleosides | EMORY UNIVERSITY (US) | 2013-04-16 | — | — | US | disclosed |
| US-20110130559-A1 | Methods to Manufacture 1,3-Dioxolane Nucleosides | GILEAD SCIENCES, INC. (US) | 2011-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110130559-A1 | Methods to Manufacture 1,3-Dioxolane Nucleosides | DCTD, AMPD1, DAD1 | LMNA 266/4885TSHR 3705/4885ALOX12 620/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.