Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 3/20 | 0.43 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CA3 | P07451 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CLK1 | P49759 | 1/20 | 0.39 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.39 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.39 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 2/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3784069 | 0.89 | ALDH1A1 (0.43) | ALDH1A1CYP3A4ALOX15HSD17B10DYRK1A | |
| SCHEMBL21629684 | 0.84 | ALDH1A1 (0.54) | ALDH1A1CYP3A4ALOX15HSD17B10MAPT | |
| SCHEMBL3786195 | 0.81 | PGR (0.43) | ALDH1A1CYP3A4HSD17B10DYRK1AMAPT | |
| SCHEMBL10956325 | 0.80 | ALDH1A1 (0.44) | ALDH1A1CYP3A4ALOX15CASP1DYRK1A | |
| Hydrochloric Acid SCHEMBL6572274 | 0.80 | PGR (0.42) | ALDH1A1CYP3A4HSD17B10DYRK1ATP53 | |
| SCHEMBL27962615 | 0.79 | CASP1 (0.52) | USP7THRBALDH1A1CA3CYP3A4 | |
| SCHEMBL11879823 | 0.79 | ESR2 (0.43) | USP7THRBALDH1A1CA3CYP3A4 | |
| SCHEMBL6571486 | 0.78 | USP7 (0.40) | USP7THRBALDH1A1CA3CYP3A4 | |
| SCHEMBL3786869 | 0.76 | MAOA (0.45) | ALDH1A1CYP3A4CASP1MAPT | |
| SCHEMBL6572455 | 0.76 | USP7 (0.35) | USP7THRBALDH1A1CA3CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8609652-B2 | Method of administering a methylene blue-curcumin analog for the treatment of alzheimer's disease | DePuy Synthes Products, LLC (US) | 2013-12-17 | — | — | US | disclosed |
| US-20110130392-A1 | Method of Administering a Methylene Blue - Curcumin Analog for the Treatment of Alzheimer's Disease | DEPUY SPINE, LLC | 2011-06-02 | — | — | US | disclosed |
| US-7906643-B2 | Methylene blue-curcumin analog for the treatment of Alzheimer's Disease | CODMAN & SHURTLEFF, INC. (US) | 2011-03-15 | — | — | US | disclosed |
| US-20100190978-A1 | METHYLENE BLUE - CURCUMIN ANALOG FOR THE TREATMENT OF ALZHEIMER'S DISEASE | CODMAN & SHURTLEFF, INC. | 2010-07-29 | — | — | US | disclosed |
| WO-2010085739-A1 | METHYLENE BLUE - CURCUMIN ANALOG FOR THE TREATMENT OF ALZHEIMER'S DISEASE | CODMAN & SHURTLEFF, INC. (US) | 2010-07-29 | — | — | WO | disclosed |
| US-7723515-B1 | Methylene blue—curcumin analog for the treatment of alzheimer's disease | CODMAN & SHURTLEFF, INC. (US) | 2010-05-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100190978-A1 | METHYLENE BLUE - CURCUMIN ANALOG FOR THE TREATMENT OF ALZHEIMER'S DISEASE | APP, PSEN2, MAPT | USP7 670/4885THRB 2018/4885ALDH1A1 441/4885 |
| US-20110130392-A1 | Method of Administering a Methylene Blue - Curcumin Analog for the Treatment of Alzheimer's Disease | APP, PSEN2, MAPT | USP7 421/4885THRB 2233/4885ALDH1A1 438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.