Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.47 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP26A1 | O43174 | 1/20 | 0.42 |
| ▸ | CYP24A1 | Q07973 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19327326 | 0.91 | ROCK2 (0.53) | ATMKMT2AMEN1TSHRROCK2 | |
| SCHEMBL19327290 | 0.90 | ROCK2 (0.54) | ALDH1A1SMN1; SMN2ATMKMT2AMEN1 | |
| SCHEMBL19327311 | 0.81 | ATM (0.56) | ALDH1A1ATMKMT2AMEN1POLB | |
| SCHEMBL19327265 | 0.80 | RAB9A (0.45) | ALDH1A1SMN1; SMN2ATMKMT2AMEN1 | |
| SCHEMBL19327267 | 0.80 | RAB9A (0.45) | ALDH1A1SMN1; SMN2ATMKMT2AMEN1 | |
| SCHEMBL19327305 | 0.77 | ATM (0.51) | ALDH1A1ATMKMT2AMEN1POLB | |
| SCHEMBL19327316 | 0.76 | ATM (0.50) | ALDH1A1ATMKMT2AMEN1POLB | |
| SCHEMBL19327318 | 0.76 | ATM (0.50) | ALDH1A1ATMKMT2AMEN1POLB | |
| SCHEMBL14177588 | 0.76 | MEN1 (0.48) | KMT2AMEN1TSHRCYP26A1CYP24A1 | |
| SCHEMBL19340071 | 0.76 | ATM (0.47) | ALDH1A1ATMKMT2AMEN1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11124503-B2 | Compositions and methods for acylating lactams | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2021-09-21 | — | — | US | disclosed |
| US-11124503-B2 | Compositions and methods for acylating lactams | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2021-09-21 | — | — | US | disclosed |
| US-20190077796-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2019-03-14 | — | — | US | disclosed |
| US-20190077796-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2019-03-14 | — | — | US | disclosed |
| EP-3426391-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | California Institute of Technology (US) | 2019-01-16 | — | — | EP | disclosed |
| US-10040784-B2 | Compositions and methods for acylating lactams | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-08-07 | — | — | US | disclosed |
| US-10040784-B2 | Compositions and methods for acylating lactams | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-08-07 | — | — | US | disclosed |
| US-10040784-B2 | Compositions and methods for acylating lactams | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-08-07 | — | — | US | disclosed |
| US-20170260172-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2017-09-14 | — | — | US | disclosed |
| US-20170260172-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2017-09-14 | — | — | US | disclosed |
| WO-2017156239-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2017-09-14 | — | — | WO | disclosed |
| US-20170260172-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2017-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11124503-B2 | Compositions and methods for acylating lactams | COASY, ASNS, NAAA | ALDH1A1 894/4885SMN1; SMN2 2602/4885ATM 3327/4885 |
| US-20170260172-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | COASY, NAAA, ASNS | ALDH1A1 1884/4885SMN1; SMN2 2690/4885ATM 2679/4885 |
| US-10040784-B2 | Compositions and methods for acylating lactams | COASY, NAAA, ASNS | ALDH1A1 1884/4885SMN1; SMN2 2690/4885ATM 2679/4885 |
| US-20190077796-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | COASY, NAAA, ASNS | ALDH1A1 1884/4885SMN1; SMN2 2690/4885ATM 2679/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.