Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19327290 | 0.91 | ROCK2 (0.54) | ROCK2ATMMEN1KMT2AMAPK1 | |
| SCHEMBL19327324 | 0.91 | ALDH1A1 (0.50) | ROCK2ATMHSD11B1MEN1KMT2A | |
| SCHEMBL19327311 | 0.85 | ATM (0.56) | ATMMEN1KMT2A | |
| SCHEMBL19327314 | 0.82 | ATM (0.46) | ATMSLC6A2SLC6A4OPRM1SIGMAR1 | |
| SCHEMBL19327305 | 0.80 | ATM (0.51) | ATMMEN1KMT2A | |
| SCHEMBL19327316 | 0.79 | ATM (0.50) | ATMOPRM1SIGMAR1MEN1KMT2A | |
| SCHEMBL19327318 | 0.79 | ATM (0.50) | ATMOPRM1SIGMAR1MEN1KMT2A | |
| SCHEMBL19327277 | 0.79 | ATM (0.47) | ATMOPRM1SIGMAR1MEN1KMT2A | |
| SCHEMBL19327278 | 0.79 | ATM (0.47) | ATMOPRM1SIGMAR1MEN1KMT2A | |
| SCHEMBL19327337 | 0.78 | ATM (0.49) | ATMOPRM1SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11124503-B2 | Compositions and methods for acylating lactams | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2021-09-21 | — | — | US | disclosed |
| US-11124503-B2 | Compositions and methods for acylating lactams | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2021-09-21 | — | — | US | disclosed |
| US-20190077796-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2019-03-14 | — | — | US | disclosed |
| US-20190077796-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2019-03-14 | — | — | US | disclosed |
| US-10040784-B2 | Compositions and methods for acylating lactams | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-08-07 | — | — | US | disclosed |
| US-10040784-B2 | Compositions and methods for acylating lactams | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-08-07 | — | — | US | disclosed |
| US-10040784-B2 | Compositions and methods for acylating lactams | CALIFORNIA INSTITUTE OF TECHNOLOGY (US) | 2018-08-07 | — | — | US | disclosed |
| US-20170260172-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2017-09-14 | — | — | US | disclosed |
| US-20170260172-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2017-09-14 | — | — | US | disclosed |
| US-20170260172-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | CALIFORNIA INSTITUTE OF TECHNOLOGY | 2017-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11124503-B2 | Compositions and methods for acylating lactams | COASY, ASNS, NAAA | ROCK2 3682/4885ATM 3327/4885SLC6A2 4233/4885 |
| US-20170260172-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | COASY, NAAA, ASNS | ROCK2 4039/4885ATM 2679/4885SLC6A2 4368/4885 |
| US-10040784-B2 | Compositions and methods for acylating lactams | COASY, NAAA, ASNS | ROCK2 4039/4885ATM 2679/4885SLC6A2 4368/4885 |
| US-20190077796-A1 | COMPOSITIONS AND METHODS FOR ACYLATING LACTAMS | COASY, NAAA, ASNS | ROCK2 4039/4885ATM 2679/4885SLC6A2 4368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.