Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 2/20 | 0.71 |
| ▸ | HTR1D | P28221 | 1/20 | 0.62 |
| ▸ | CHRNA7 | P36544 | 9/20 | 0.59 |
| ▸ | CHRNA10 | Q9GZZ6 | 5/20 | 0.59 |
| ▸ | CHRNA9 | Q9UGM1 | 5/20 | 0.59 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.59 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | RELA | Q04206 | 1/20 | 0.59 |
| ▸ | PPARA | Q07869 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19327366 | 1.00 | HTR1B (0.71) | HTR1BHTR1DCHRNA7CHRNA10CHRNA9 | |
| SCHEMBL19353545 | 0.84 | NFE2L2 (0.58) | HTR1BRELA | |
| SCHEMBL1109801 | 0.84 | HTR1B (1.00) | HTR1BHTR1DL3MBTL1KDM4EMEN1 | |
| SCHEMBL19353611 | 0.83 | NFE2L2 (0.55) | HTR1BHTR1DL3MBTL1CYP1A2 | |
| SCHEMBL5741015 | 0.82 | RELA (0.72) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| SCHEMBL1618632 | 0.82 | RELA (0.72) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| SCHEMBL13886634 | 0.81 | HTR1B (0.85) | HTR1BHTR1DL3MBTL1KDM4EMEN1 | |
| SCHEMBL24133448 | 0.80 | APP (0.74) | HTR1BCHRNA7CHRNA10CHRNA9L3MBTL1 | |
| SCHEMBL17609108 | 0.79 | CHRNA7 (0.63) | CHRNA7CHRNA10CHRNA9CHRNB4CHRNA3 | |
| SCHEMBL1470314 | 0.79 | ALDH1A1 (0.60) | HTR1BHTR1DL3MBTL1MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170260126-A1 | SQUALENE COMPOUNDS AS MODULATORS OF LDL-RECEPTOR EXPRESSION | UNIV OXFORD INNOVATION LTD (GB) | 2017-09-14 | — | — | US | claimed |
| US-20170260126-A1 | SQUALENE COMPOUNDS AS MODULATORS OF LDL-RECEPTOR EXPRESSION | UNIV OXFORD INNOVATION LTD (GB) | 2017-09-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170260126-A1 | SQUALENE COMPOUNDS AS MODULATORS OF LDL-RECEPTOR EXPRESSION | LDLR, NR1H2, SREBF1 | HTR1B 1308/4885HTR1D 1400/4885CHRNA7 1175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.