Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.42 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.42 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.42 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.42 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.42 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.41 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.41 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19331376 | 0.84 | TACR1 (0.43) | SMN1; SMN2KDM4EATM | |
| SCHEMBL8283182 | 0.83 | HTR1A (0.50) | SMN1; SMN2AKT1AKT2CYP4F2CYP4A11 | |
| SCHEMBL15054711 | 0.74 | L3MBTL1 (0.46) | SMN1; SMN2KDM4EATM | |
| SCHEMBL19343286 | 0.73 | KMT2A (0.53) | OPRM1AKT1AKT2KDM4E | |
| SCHEMBL5000848 | 0.72 | SMN1; SMN2 (0.45) | SMN1; SMN2CYP4F2CYP4A11ATM | |
| SCHEMBL615716 | 0.72 | SMN1; SMN2 (0.46) | SMN1; SMN2ALOX5CYP4F2CYP4A11KDM4E | |
| SCHEMBL1670244 | 0.71 | LOXL2 (0.51) | GRIN2DGRIN3BOPRM1GRIN1GRIN2A | |
| SCHEMBL27699787 | 0.71 | TP53 (0.47) | SMN1; SMN2CYP4F2CYP4A11KDM4ENPC1 | |
| SCHEMBL19382551 | 0.71 | SMN1; SMN2 (0.48) | SMN1; SMN2ALOX5CYP4F2CYP4A11CDC25B | |
| SCHEMBL16418421 | 0.70 | OPRM1 (0.73) | GRIN2DGRIN3BCHRM2CHRM1OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426243-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | Raze Therapeutics Inc. (US) | 2019-01-16 | — | — | EP | disclosed |
| WO-2017156165-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |