Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.57 |
| ▸ | ACHE | P22303 | 11/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.44 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.44 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10440897 | 0.84 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL5224263 | 0.82 | SMN1; SMN2 (0.55) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL27770721 | 0.82 | MTNR1A (0.50) | HPGD | |
| SCHEMBL7431205 | 0.80 | SLC1A3 (0.64) | SMN1; SMN2LMNAL3MBTL1 | |
| SCHEMBL9774159 | 0.79 | LMNA (0.49) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| Hydrochloric Acid SCHEMBL9774150 | 0.78 | LMNA (0.48) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL2052808 | 0.78 | SMN1; SMN2 (0.56) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL15738570 | 0.77 | SMN1; SMN2 (0.92) | NPC1RAB9ASMN1; SMN2LMNAPOLB | |
| SCHEMBL28335649 | 0.77 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2LMNAACHE | |
| SCHEMBL10318441 | 0.77 | MEN1 (0.50) | ALDH1A1CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426244-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | Raze Therapeutics Inc. (US) | 2019-01-16 | — | — | EP | disclosed |
| WO-2017156179-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |