Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | ACHE | P22303 | 7/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | FNTA | P49354 | 3/20 | 0.43 |
| ▸ | FNTB | P49356 | 3/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.42 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3663783 | 0.87 | RAB9A (0.64) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL10440897 | 0.82 | NPC1 (0.57) | SMN1; SMN2NPC1RAB9ALMNAACHE | |
| SCHEMBL19331815 | 0.82 | NPC1 (0.57) | SMN1; SMN2NPC1RAB9ALMNAACHE | |
| SCHEMBL6251493 | 0.81 | RAB9A (0.63) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL9468152 | 0.79 | ALDH1A1 (0.50) | SMN1; SMN2NPC1RAB9ALMNAALDH1A1 | |
| SCHEMBL2289954 | 0.78 | GABBR2 (0.58) | POLBFNTAFNTBGABBR2GABBR1 | |
| SCHEMBL3661888 | 0.77 | ACHE (0.54) | ACHECHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL14040614 | 0.76 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL844472 | 0.76 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9ALMNAPOLB | |
| SCHEMBL7663044 | 0.76 | GABBR2 (0.56) | POLBGABBR2GABBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781649-A2 | SUBSTITUTED HYDANTOINS | F. Hoffmann-Roche AG (CH) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018188-A2 | SUBSTITUTED HYDANTOINS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-02-23 | — | — | WO | disclosed |