Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 5/20 | 0.38 |
| ▸ | CTSK | P43235 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 3/20 | 0.34 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.34 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | P4HB | P07237 | 1/20 | 0.31 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19332285 | 1.00 | CTSS (0.38) | CTSSCTSKMEN1KMT2ANFKB1 | |
| SCHEMBL19332567 | 0.83 | ERN1 (0.32) | — | |
| SCHEMBL19332569 | 0.83 | ERN1 (0.32) | — | |
| SCHEMBL19331303 | 0.82 | LMNA (0.40) | MEN1KMT2ANPC1MAPTRAB9A | |
| SCHEMBL19331299 | 0.82 | LMNA (0.40) | MEN1KMT2ANPC1MAPTRAB9A | |
| SCHEMBL19331004 | 0.80 | MEN1 (0.32) | MEN1KMT2ARAB9A | |
| SCHEMBL19332730 | 0.80 | MEN1 (0.32) | MEN1KMT2ARAB9A | |
| SCHEMBL19331001 | 0.80 | MEN1 (0.32) | MEN1KMT2ARAB9A | |
| SCHEMBL19332733 | 0.80 | MEN1 (0.32) | MEN1KMT2ARAB9A | |
| SCHEMBL19332511 | 0.80 | HSD11B1 (0.31) | MRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017156181-A1 | 3-PHOSPHOGLYCERATE DEHYDROGENASE INHIBITORS AND USES THEREOF | RAZE THERAPEUTICS, INC. (US) | 2017-09-14 | — | — | WO | disclosed |