Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 13/20 | 0.63 |
| ▸ | MTOR | P42345 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | SRC | P12931 | 2/20 | 0.55 |
| ▸ | FLT3 | P36888 | 2/20 | 0.55 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.55 |
| ▸ | KIT | P10721 | 1/20 | 0.55 |
| ▸ | SIK1 | P57059 | 1/20 | 0.55 |
| ▸ | RIPK4 | P57078 | 1/20 | 0.55 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.55 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.55 |
| ▸ | DSTYK | Q6XUX3 | 1/20 | 0.55 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.55 |
| ▸ | ADK | P55263 | 3/20 | 0.53 |
| ▸ | PIKFYVE | Q9Y2I7 | 2/20 | 0.53 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | PAK4 | O96013 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1933267 | 1.00 | RIPK2 (0.63) | RIPK2MTORRAB9ASRCFLT3 | |
| SCHEMBL16237288 | 0.94 | SRC (0.59) | RIPK2MTORRAB9ASRCFLT3 | |
| SCHEMBL30155310 | 0.88 | ABL1 (0.64) | MTORRAB9ASRCFLT3PDGFRB | |
| SCHEMBL29484468 | 0.88 | SRC (0.61) | MTORRAB9ASRCFLT3PDGFRB | |
| SCHEMBL400626 | 0.88 | SRC (0.61) | MTORRAB9ASRCFLT3PDGFRB | |
| SCHEMBL1940882 | 0.88 | ABL1 (0.64) | MTORRAB9ASRCFLT3PDGFRB | |
| SCHEMBL9950847 | 0.87 | ADK (0.62) | RIPK2MTORRAB9ASRCFLT3 | |
| SCHEMBL9950846 | 0.87 | ADK (0.62) | RIPK2MTORRAB9ASRCFLT3 | |
| SCHEMBL17818397 | 0.87 | ABL1 (0.63) | MTORRAB9ASRCFLT3PDGFRB | |
| SCHEMBL19743265 | 0.86 | SRC (0.52) | RIPK2MTORRAB9ASRCFLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120289501-A1 | Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls | NOVARTIS AG (CH) | 2012-11-15 | — | — | US | disclosed |
| EP-2504339-A1 | BENZENE-FUSED 6-MEMBERED OXYGEN-CONTAINING HETEROCYCLIC DERIVATIVES OF BICYCLIC HETEROARYLS | Novartis AG (CH) | 2012-10-03 | — | — | EP | disclosed |
| CN-102712648-A | Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls | NOVARTIS AG | 2012-10-03 | — | — | CN | disclosed |
| WO-2011064211-A1 | BENZENE-FUSED 6-MEMBERED OXYGEN-CONTAINING HETEROCYCLIC DERIVATIVES OF BICYCLIC HETEROARYLS | NOVARTIS AG (CH) | 2011-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120289501-A1 | Benzene-fused 6-membered oxygen-containing heterocyclic derivatives of bicyclic heteroaryls | CYP1B1, CYP11B2, CCNI | RIPK2 4726/4885MTOR 926/4885RAB9A 3325/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.