Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 7/20 | 0.64 |
| ▸ | LCK | P06239 | 4/20 | 0.64 |
| ▸ | RET | P07949 | 3/20 | 0.64 |
| ▸ | KDR | P35968 | 3/20 | 0.64 |
| ▸ | CSF1R | P07333 | 2/20 | 0.64 |
| ▸ | IGF1R | P08069 | 2/20 | 0.64 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.64 |
| ▸ | FLT1 | P17948 | 2/20 | 0.64 |
| ▸ | FLT3 | P36888 | 2/20 | 0.64 |
| ▸ | MST1R | Q04912 | 2/20 | 0.64 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.64 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.64 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.64 |
| ▸ | FYN | P06241 | 2/20 | 0.64 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.64 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.64 |
| ▸ | PAK4 | O96013 | 1/20 | 0.64 |
| ▸ | PRKACA | P17612 | 1/20 | 0.64 |
| ▸ | LTK | P29376 | 1/20 | 0.64 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1940882 | 1.00 | ABL1 (0.64) | ABL1LCKRETKDRCSF1R | |
| SCHEMBL17818397 | 0.98 | ABL1 (0.63) | ABL1LCKRETKDRCSF1R | |
| SCHEMBL400626 | 0.97 | SRC (0.61) | ABL1LCKRETKDRCSF1R | |
| SCHEMBL29484468 | 0.97 | SRC (0.61) | ABL1LCKRETKDRCSF1R | |
| SCHEMBL16237288 | 0.94 | SRC (0.59) | ABL1LCKRETKDRCSF1R | |
| SCHEMBL1933264 | 0.88 | RIPK2 (0.63) | ABL1LCKRETKDRCSF1R | |
| SCHEMBL1933267 | 0.88 | RIPK2 (0.63) | ABL1LCKRETKDRCSF1R | |
| SCHEMBL9950847 | 0.87 | ADK (0.62) | ABL1LCKRETKDRCSF1R | |
| SCHEMBL9950846 | 0.87 | ADK (0.62) | ABL1LCKRETKDRCSF1R | |
| SCHEMBL19743649 | 0.87 | FGR (0.57) | ABL1LCKRETKDRCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022261352-A1 | PERFLUOROALKANE SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDIN AND PYRROLO[2,3-D]PYRIMIDIN COMPOUNDS AND USES THEREOF | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-12-15 | — | — | WO | disclosed |