Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADK | P55263 | 11/20 | 0.62 |
| ▸ | SRC | P12931 | 3/20 | 0.60 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.60 |
| ▸ | LCK | P06239 | 2/20 | 0.60 |
| ▸ | FYN | P06241 | 2/20 | 0.60 |
| ▸ | RET | P07949 | 2/20 | 0.60 |
| ▸ | PRKACA | P17612 | 2/20 | 0.60 |
| ▸ | KDR | P35968 | 2/20 | 0.60 |
| ▸ | CSNK1A1 | P48729 | 2/20 | 0.60 |
| ▸ | CLK2 | P49760 | 2/20 | 0.60 |
| ▸ | LIMK1 | P53667 | 2/20 | 0.60 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.60 |
| ▸ | MAP4K2 | Q12851 | 2/20 | 0.60 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.60 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.60 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.60 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.60 |
| ▸ | CDC7 | O00311 | 1/20 | 0.60 |
| ▸ | PLK4 | O00444 | 1/20 | 0.60 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9950846 | 1.00 | ADK (0.62) | ADKSRCMAP4K4LCKFYN | |
| SCHEMBL16237288 | 0.93 | SRC (0.59) | ADKSRCMAP4K4LCKFYN | |
| SCHEMBL1933267 | 0.87 | RIPK2 (0.63) | ADKSRCMAP4K4LCKFYN | |
| SCHEMBL1933264 | 0.87 | RIPK2 (0.63) | ADKSRCMAP4K4LCKFYN | |
| SCHEMBL29484468 | 0.87 | SRC (0.61) | ADKSRCMAP4K4LCKFYN | |
| SCHEMBL400626 | 0.87 | SRC (0.61) | ADKSRCMAP4K4LCKFYN | |
| SCHEMBL1940882 | 0.87 | ABL1 (0.64) | ADKSRCMAP4K4LCKFYN | |
| SCHEMBL30155310 | 0.87 | ABL1 (0.64) | ADKSRCMAP4K4LCKFYN | |
| SCHEMBL17818397 | 0.86 | ABL1 (0.63) | ADKSRCMAP4K4LCKFYN | |
| SCHEMBL9951321 | 0.85 | SRC (0.53) | ADKSRCLCKRETKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012120469-A1 | FLUOROPHENYL BICYCLIC HETEROARYL COMPOUNDS | NOVARTIS AG (CH) | 2012-09-13 | — | — | WO | disclosed |
| US-20120165310-A1 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS | NOVARTIS AG (CH) | 2012-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120165310-A1 | ETHER DERIVATIVES OF BICYCLIC HETEROARYLS | ETV6, CYP11B2, CYP11B1 | ADK 3449/4885SRC 292/4885MAP4K4 1535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.