Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.40 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.40 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.40 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.40 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.40 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.40 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7256852 | 0.79 | ALDH1A1 (0.56) | EGFRPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL7262295 | 0.75 | ALDH1A1 (0.57) | EGFRALDH1A1KDM4ENPC1CYP3A4 | |
| SCHEMBL31140520 | 0.74 | GPR84 (0.53) | IDO1ALDH1A1KDM4ECYP3A4RAB9A | |
| SCHEMBL24825685 | 0.72 | ALDH1A1 (0.42) | EGFRALDH1A1KDM4EHSD17B10ABCG2 | |
| SCHEMBL8604209 | 0.70 | EGFR (0.44) | EGFRALDH1A1KDM4ECYP3A4HSD17B10 | |
| SCHEMBL1933114 | 0.67 | EGFR (0.57) | EGFRPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL9665811 | 0.67 | HTR2B (0.53) | ABCG2MEN1MAPTKMT2ANPSR1 | |
| SCHEMBL7256744 | 0.67 | EGFR (0.70) | EGFRPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL2494130 | 0.67 | EGFR (0.51) | EGFRPRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL2430311 | 0.66 | ALDH1A1 (0.52) | EGFRKITALDH1A1KDM4ENPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011066606-A1 | PYRANOINDOLE COMPOUNDS AND USES THEREOF | NOVOGEN RESEARCH PTY LTD (AU) | 2011-06-09 | — | — | WO | disclosed |