Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 9/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | NT5E | P21589 | 2/20 | 0.66 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.53 |
| ▸ | ACP1 | P24666 | 2/20 | 0.53 |
| ▸ | PTPRF | P10586 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | F3 | P13726 | 1/20 | 0.48 |
| ▸ | PNLIP | P16233 | 1/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.48 |
| ▸ | USP7 | Q93009 | 1/20 | 0.46 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.42 |
| ▸ | ALB | P02768 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GLI1 | P08151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14344859 | 1.00 | GPBAR1 (0.66) | GPBAR1LMNASMN1; SMN2NT5EPTPN1 | |
| SCHEMBL10074445 | 0.88 | GPBAR1 (0.57) | GPBAR1LMNASMN1; SMN2NT5EPTPN1 | |
| SCHEMBL18687847 | 0.86 | GPBAR1 (0.65) | GPBAR1LMNASMN1; SMN2NT5EPTPN1 | |
| SCHEMBL25464092 | 0.83 | USP7 (0.51) | GPBAR1LMNASMN1; SMN2NT5EPTPN1 | |
| SCHEMBL21149779 | 0.83 | LMNA (0.53) | GPBAR1LMNASMN1; SMN2NT5EPTPN1 | |
| SCHEMBL12332942 | 0.83 | GPBAR1 (0.75) | GPBAR1LMNASMN1; SMN2NT5EPTPN1 | |
| SCHEMBL13759952 | 0.82 | LMNA (0.52) | GPBAR1LMNASMN1; SMN2NT5EPTPN1 | |
| SCHEMBL13759951 | 0.82 | LMNA (0.52) | GPBAR1LMNASMN1; SMN2NT5EPTPN1 | |
| SCHEMBL19415286 | 0.82 | LMNA (0.49) | GPBAR1LMNASMN1; SMN2NT5EPTPN1 | |
| SCHEMBL15947464 | 0.82 | LMNA (0.49) | GPBAR1LMNASMN1; SMN2NT5EPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2814834-B1 | C-3 CYCLOALKENYL TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY | VIIV HEALTHCARE UK (NO 5) LTD (GB) | 2017-09-13 | — | — | EP | disclosed |