Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14606392 | 0.76 | PTGDR2 (0.46) | CA1CA2CA9PTGDR2GPR119 | |
| SCHEMBL19738042 | 0.76 | CA2 (0.47) | CA1CA2CA9PTGDR2GPR119 | |
| SCHEMBL1725785 | 0.76 | PTGDR2 (0.44) | CA1CA2CA9PTGDR2 | |
| SCHEMBL31028753 | 0.76 | PTGDR2 (0.44) | CA1CA2CA9PTGDR2 | |
| SCHEMBL2817739 | 0.76 | CA9 (0.46) | CA1CA2CA9PTGDR2LMNA | |
| SCHEMBL21028294 | 0.73 | CA1 (0.40) | CA1CA2CA9PTGDR2GPR119 | |
| SCHEMBL12604601 | 0.73 | CA1 (0.40) | CA1CA2CA9PTGDR2LMNA | |
| SCHEMBL17986394 | 0.72 | CTSL (0.48) | CA1CA2CA9PTGDR2GABRA2 | |
| SCHEMBL8110972 | 0.72 | ALDH1A1 (0.50) | CA1CA2CA9PTGDR2 | |
| SCHEMBL17168925 | 0.72 | DRD2 (0.42) | CA1CA2CA9PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966214-B9 | TRIAZOLOPYRIDAZINES AS TYROSINE KINASE MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-13 | — | — | EP | disclosed |