Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.39 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
| ▸ | MMP9 | P14780 | 2/20 | 0.39 |
| ▸ | MMP8 | P22894 | 2/20 | 0.39 |
| ▸ | MMP13 | P45452 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10201483 | 0.92 | CACNA1G (0.39) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL19488323 | 0.86 | NPSR1 (0.51) | HDAC6CACNA1GCACNA1BCACNA1CALDH1A1 | |
| SCHEMBL19883604 | 0.85 | LMNA (0.37) | HDAC3HDAC1HDAC2CACNA1GCACNA1B | |
| SCHEMBL19488867 | 0.85 | KDM4E (0.48) | HDAC3HDAC1HDAC2MMP2MMP9 | |
| SCHEMBL19339742 | 0.85 | GABRA1 (0.39) | HDAC3HDAC1HDAC2HDAC6CACNA1G | |
| SCHEMBL19488634 | 0.84 | NPSR1 (0.38) | HDAC3HDAC1HDAC2CACNA1GCACNA1B | |
| SCHEMBL19488842 | 0.84 | NPSR1 (0.38) | HDAC3HDAC1HDAC2HDAC6CACNA1G | |
| SCHEMBL10200220 | 0.81 | CACNA1G (0.39) | HDAC3HDAC1HDAC2CACNA1GCACNA1B | |
| SCHEMBL10202452 | 0.78 | GABRA1 (0.41) | HDAC3HDAC1HDAC2CACNA1GCACNA1B | |
| SCHEMBL19488627 | 0.78 | ALDH1A1 (0.48) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3002281-B1 | ANTIVIRAL COMPOUNDS | GILEAD PHARMASSET LLC (US) | 2017-09-13 | — | — | EP | disclosed |