Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 7/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 6/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23584806 | 0.96 | CNR2 (0.37) | GPR119MAP4K4FAAHOPRD1OPRK1 | |
| SCHEMBL23584795 | 0.91 | CNR2 (0.37) | GPR119MAP4K4OPRD1OPRK1BACE1 | |
| SCHEMBL22434806 | 0.91 | CNR2 (0.37) | GPR119MAP4K4OPRD1OPRK1BACE1 | |
| SCHEMBL23584488 | 0.87 | RIPK1 (0.34) | GPR119MAP4K4OPRD1OPRK1NAMPT | |
| SCHEMBL23584808 | 0.82 | EIF2AK4 (0.35) | MAP4K4NAMPTRIPK1 | |
| SCHEMBL19344509 | 0.82 | CNR2 (0.40) | MAP4K4BACE1NAMPTRIPK1 | |
| SCHEMBL23584768 | 0.82 | CNR2 (0.40) | MAP4K4BACE1NAMPTRIPK1 | |
| SCHEMBL22435090 | 0.81 | OPRD1 (0.34) | MAP4K4FAAHOPRD1OPRK1BACE1 | |
| SCHEMBL23584737 | 0.80 | CNR2 (0.38) | GPR119OPRD1OPRK1BACE1NAMPT | |
| SCHEMBL23584495 | 0.79 | PRMT5 (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3426664-B1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2021-06-30 | — | — | EP | disclosed |
| WO-2017153186-A1 | SUBSTITUTED NUCLEOSIDE ANALOGUES FOR USE AS PRMT5 INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2017-09-14 | — | — | WO | disclosed |