Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 7/20 | 0.53 |
| ▸ | CYP2E1 | P05181 | 7/20 | 0.53 |
| ▸ | CYP2C8 | P10632 | 7/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 7/20 | 0.53 |
| ▸ | CYP2B6 | P20813 | 7/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 7/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.53 |
| ▸ | PLAU | P00749 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GLA | P06280 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19330726 | 0.90 | LMNA (0.52) | CYP1A2CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL10532253 | 0.82 | CYP1A2 (0.48) | CYP1A2CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL1563025 | 0.80 | CYP1A2 (0.64) | CYP1A2CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL6757973 | 0.79 | HSD17B10 (0.56) | CYP1A2CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL6755646 | 0.79 | MAPT (0.65) | CYP1A2CYP2E1CYP2C8CYP2D6CYP2C9 | |
| Hydrochloric Acid SCHEMBL27677173 | 0.76 | AR (0.55) | CYP1A2CYP2E1CYP2C8CYP2D6CYP2C9 | |
| SCHEMBL6759921 | 0.75 | BCHE (0.71) | LMNAMAPTRAB9ANPC1BCHE | |
| SCHEMBL6759851 | 0.75 | BCHE (0.71) | LMNAMAPTRAB9ANPC1BCHE | |
| SCHEMBL6530086 | 0.74 | BCHE (0.83) | LMNARAB9ANPC1BCHEPOLB | |
| Hydrochloric Acid SCHEMBL28882568 | 0.73 | BCHE (0.80) | LMNARAB9ANPC1BCHEPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10407421-B2 | Bicyclic aryl monobactam compounds and methods of use thereof for the treatment of bacterial infections | MERCK SHARP & DOHME CORP (US) | 2019-09-10 | — | — | US | disclosed |
| US-20190071436-A1 | BICYCLIC ARYL MONOBACTAM COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF BACTERIAL INFECTIONS | MERCK SHARP & DOHME CORP. (US) | 2019-03-07 | — | — | US | disclosed |
| WO-2017155765-A1 | BICYCLIC ARYL MONOBACTAM COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF BACTERIAL INFECTIONS | MERCK SHARP & DOHME CORP. (US) | 2017-09-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10407421-B2 | Bicyclic aryl monobactam compounds and methods of use thereof for the treatment of bacterial infections | MGAM, BMX, XDH | CYP1A2 107/4885CYP2E1 716/4885CYP2C8 681/4885 |
| US-20190071436-A1 | BICYCLIC ARYL MONOBACTAM COMPOUNDS AND METHODS OF USE THEREOF FOR THE TREATMENT OF BACTERIAL INFECTIONS | MGAM, BMX, XDH | CYP1A2 107/4885CYP2E1 716/4885CYP2C8 681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.