Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.42 |
| ▸ | ACP3 | P15309 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9243396 | 0.83 | MEN1 (0.41) | HTTOPRM1L3MBTL1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9568027 | 0.75 | TRPM8 (0.46) | HTTTRPM8 | |
| SCHEMBL27129419 | 0.74 | ALDH1A1 (0.38) | HTTTSHRNPSR1L3MBTL1SLC6A3 | |
| SCHEMBL26984334 | 0.74 | ALDH1A1 (0.38) | HTTTSHRNPSR1L3MBTL1SLC6A3 | |
| SCHEMBL10739890 | 0.74 | ACP3 (0.47) | HTTOPRM1ACP3TSHRNPSR1 | |
| SCHEMBL9568023 | 0.73 | TRPM8 (0.48) | HTTTSHRTRPM8L3MBTL1DHODH | |
| SCHEMBL9241163 | 0.71 | HTR2A (0.44) | HTTACP3TSHRNPSR1HTR2C | |
| SCHEMBL7566016 | 0.71 | HTR2A (0.44) | HTTACP3TSHRNPSR1HTR2C | |
| SCHEMBL9242330 | 0.71 | HTR2A (0.44) | HTTACP3TSHRNPSR1HTR2C | |
| SCHEMBL31757646 | 0.71 | MEN1 (0.39) | TSHRL3MBTL1SLC6A3ALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9988390-B2 | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease | HOFFMANN LA ROCHE (CH) | 2018-06-05 | — | — | US | disclosed |
| US-20170267680-A1 | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease | HOFFMANN LA ROCHE (CH) | 2017-09-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170267680-A1 | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease | XDH, HPRT1, IMPDH1 | HTT 1950/4885OPRM1 614/4885ACP3 1816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.