Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 2/20 | 0.43 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.42 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.39 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19348564 | 0.85 | ADAM17 (0.44) | OPRM1OPRL1EPHX2ALDH1A1DPP4 | |
| SCHEMBL19385743 | 0.81 | OPRM1 (0.46) | OPRM1OPRL1EPHX2GRM2GRM3 | |
| SCHEMBL2640274 | 0.81 | EPHX2 (0.47) | OPRM1OPRL1EPHX2GRM2GRM3 | |
| SCHEMBL31471348 | 0.80 | EPHX2 (0.46) | OPRM1OPRL1EPHX2GRM2GRM3 | |
| SCHEMBL32676611 | 0.79 | EPHX2 (0.44) | OPRM1OPRL1EPHX2ALDH1A1CTSL | |
| SCHEMBL28543821 | 0.79 | OPRM1 (0.49) | OPRM1OPRL1EPHX2ALDH1A1CTSL | |
| SCHEMBL15927870 | 0.79 | OPRM1 (0.43) | OPRM1OPRL1EPHX2GRM2GRM3 | |
| SCHEMBL14409083 | 0.78 | GRM2 (0.47) | OPRM1OPRL1EPHX2GRM2GRM3 | |
| SCHEMBL296907 | 0.78 | GRM2 (0.47) | OPRM1OPRL1EPHX2GRM2GRM3 | |
| SCHEMBL9960560 | 0.78 | EPHX2 (0.45) | OPRM1OPRL1EPHX2GRM2GRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10183928-B2 | Inhibitors of RET | BLUEPRINT MEDICINES CORPORATION (US) | 2019-01-22 | — | — | US | disclosed |
| US-10183928-B2 | Inhibitors of RET | BLUEPRINT MEDICINES CORPORATION (US) | 2019-01-22 | — | — | US | disclosed |
| US-20170267661-A1 | INHIBITORS OF RET | BLUEPRINT MEDICINES CORPORATION | 2017-09-21 | — | — | US | disclosed |
| US-20170267661-A1 | INHIBITORS OF RET | BLUEPRINT MEDICINES CORPORATION | 2017-09-21 | — | — | US | disclosed |
| WO-2017161269-A1 | INHIBITORS OF RET RECEPTOR TYROSINE KINASES | BLUEPRINT MEDICINES CORPORATION (US) | 2017-09-21 | — | — | WO | disclosed |
| WO-2017161269-A1 | INHIBITORS OF RET RECEPTOR TYROSINE KINASES | BLUEPRINT MEDICINES CORPORATION (US) | 2017-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10183928-B2 | Inhibitors of RET | RET, HRAS, RB1 | OPRM1 2549/4885OPRL1 3171/4885EPHX2 3070/4885 |
| US-20170267661-A1 | INHIBITORS OF RET | RET, HRAS, RB1 | OPRM1 2549/4885OPRL1 3171/4885EPHX2 3070/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.