Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL871442 | 0.85 | ADAM17 (0.46) | ADAM17EPHX2TSHRALDH1A1L3MBTL1 | |
| SCHEMBL19348562 | 0.85 | OPRM1 (0.43) | EPHX2TSHRALDH1A1L3MBTL1CYP3A4 | |
| SCHEMBL15927866 | 0.84 | ADAM17 (0.46) | ADAM17EPHX2TSHRALDH1A1L3MBTL1 | |
| SCHEMBL8053435 | 0.83 | ADAM17 (0.45) | ADAM17EPHX2TSHRALDH1A1L3MBTL1 | |
| SCHEMBL15306513 | 0.83 | ADAM17 (0.45) | ADAM17EPHX2TSHRALDH1A1L3MBTL1 | |
| SCHEMBL297404 | 0.83 | ADAM17 (0.45) | ADAM17EPHX2TSHRALDH1A1L3MBTL1 | |
| SCHEMBL12277199 | 0.83 | LMNA (0.46) | ADAM17EPHX2TSHRALDH1A1L3MBTL1 | |
| Hydrochloric Acid SCHEMBL8049068 | 0.82 | ADAM17 (0.44) | ADAM17EPHX2TSHRALDH1A1L3MBTL1 | |
| SCHEMBL8050802 | 0.81 | ADAM17 (0.43) | ADAM17EPHX2TSHRALDH1A1L3MBTL1 | |
| SCHEMBL8049066 | 0.81 | EPHX2 (0.44) | ADAM17EPHX2TSHRALDH1A1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10183928-B2 | Inhibitors of RET | BLUEPRINT MEDICINES CORPORATION (US) | 2019-01-22 | — | — | US | disclosed |
| US-20170267661-A1 | INHIBITORS OF RET | BLUEPRINT MEDICINES CORPORATION | 2017-09-21 | — | — | US | disclosed |
| WO-2017161269-A1 | INHIBITORS OF RET RECEPTOR TYROSINE KINASES | BLUEPRINT MEDICINES CORPORATION (US) | 2017-09-21 | — | — | WO | disclosed |
| WO-2017161269-A1 | INHIBITORS OF RET RECEPTOR TYROSINE KINASES | BLUEPRINT MEDICINES CORPORATION (US) | 2017-09-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10183928-B2 | Inhibitors of RET | RET, HRAS, RB1 | ADAM17 2736/4885EPHX2 3070/4885TSHR 2226/4885 |
| US-20170267661-A1 | INHIBITORS OF RET | RET, HRAS, RB1 | ADAM17 2736/4885EPHX2 3070/4885TSHR 2226/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.