Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRB | P09619 | 1/20 | 0.53 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.53 |
| ▸ | GRK6 | P43250 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.44 |
| ▸ | TUBB | P07437 | 1/20 | 0.44 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.44 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.44 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.44 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.44 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.44 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.44 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28075509 | 0.84 | GRK6 (0.60) | PDGFRBPDGFRAGRK6ALDH1A1MAPT | |
| SCHEMBL19356089 | 0.82 | KDM4E (0.60) | ALDH1A1MAPTMEN1KMT2AKDM4E | |
| SCHEMBL28075560 | 0.81 | GRK6 (0.55) | PDGFRBPDGFRAGRK6ALDH1A1MAPT | |
| SCHEMBL9566549 | 0.81 | PDGFRB (0.57) | PDGFRBPDGFRAGRK6ALDH1A1MAPT | |
| SCHEMBL28075564 | 0.81 | GRK6 (0.54) | PDGFRBPDGFRAGRK6ALDH1A1LMNA | |
| SCHEMBL11887848 | 0.80 | DHFR (0.52) | ALDH1A1MAPTMEN1POLBKMT2A | |
| SCHEMBL28075567 | 0.79 | GRK6 (0.50) | PDGFRBPDGFRAGRK6ALDH1A1MAPT | |
| SCHEMBL28075506 | 0.78 | NR1H2 (0.61) | PDGFRBPDGFRAGRK6ALDH1A1MAPT | |
| SCHEMBL4680875 | 0.77 | GRK6 (0.53) | GRK6 | |
| SCHEMBL30955240 | 0.76 | ALDH1A1 (0.67) | PDGFRBPDGFRAGRK6ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017152842-A1 | KINASE INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2017-09-14 | — | — | WO | disclosed |