Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 5/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 5/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.37 |
| ▸ | CCNK | O75909 | 7/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 7/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 6/20 | 0.37 |
| ▸ | CDK2 | P24941 | 6/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | SSTR4 | P31391 | 1/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.34 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.34 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.34 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.34 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1935663 | 1.00 | MAPK8 (0.37) | MAPK8MAPK9MAPK10CCNKCDK12 | |
| SCHEMBL1937258 | 0.89 | GAA (0.37) | CCNKCDK12CCNA2CDK2GAA | |
| SCHEMBL1937259 | 0.89 | GAA (0.37) | CCNKCDK12CCNA2CDK2GAA | |
| SCHEMBL1938097 | 0.83 | SYK (0.40) | MAPK8MAPK9CDK2MAP4K4HCAR3 | |
| SCHEMBL1938096 | 0.83 | SYK (0.40) | MAPK8MAPK9CDK2MAP4K4HCAR3 | |
| SCHEMBL2179809 | 0.83 | MTOR (0.34) | L3MBTL1KDM4EMAPTTDP1STK17A | |
| SCHEMBL2179806 | 0.83 | MTOR (0.34) | L3MBTL1KDM4EMAPTTDP1STK17A | |
| SCHEMBL1936695 | 0.83 | GPR65 (0.38) | CCNKCDK12CCNA2CDK2DPP4 | |
| SCHEMBL1936697 | 0.83 | GPR65 (0.38) | CCNKCDK12CCNA2CDK2DPP4 | |
| SCHEMBL3631690 | 0.83 | MAPK8 (0.41) | MAPK8MAPK9MAPK10GAAL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110166161-A1 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | ASTELLAS PHARMA INC. (JP) | 2011-07-07 | — | — | US | disclosed |
| EP-2331507-A2 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | Astellas Pharma Inc. (JP) | 2011-06-15 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110166161-A1 | HETEROCYCLIC CARBOXAMIDE COMPOUNDS | ROCK1, ROCK2, RHOT2 | MAPK8 717/4885MAPK9 802/4885MAPK10 484/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.