Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.50 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 2/20 | 0.48 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CES2 | O00748 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13208856 | 0.89 | — | — | |
| SCHEMBL206647 | 0.89 | — | — | |
| Bromide SCHEMBL23360798 | 0.87 | DPP4 (0.55) | LMNAMAPK1ADRA2AADRA2CHIF1A | |
| Hydrochloric Acid SCHEMBL2565646 | 0.87 | ALDH1A1 (0.58) | LMNAMAPK1ADRA2AADRA2CHIF1A | |
| SCHEMBL31318946 | 0.87 | DPP4 (0.55) | LMNAMAPK1ADRA2AADRA2CHIF1A | |
| Nitrogen SCHEMBL28373188 | 0.84 | DPP4 (0.52) | LMNAMAPK1ADRA2AADRA2CHIF1A | |
| Carbamic Acid SCHEMBL30873811 | 0.79 | HDAC1 (0.54) | LMNAMAPK1EPHX1CYP2D6SRC | |
| Phenyl Ethanol SCHEMBL28164236 | 0.78 | ALOX5 (0.53) | LMNAMAPK1BCAT2ADRA2AADRA2C | |
| Phenyl Ethanol SCHEMBL28164234 | 0.78 | ALOX5 (0.53) | LMNAMAPK1BCAT2ADRA2AADRA2C | |
| Mandelic Acid SCHEMBL11083521 | 0.78 | LMNA (0.86) | LMNAMAPK1EPHX1BCAT2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3429586-A1 | TARGETING TUMOR CELLS WITH CHEMOTHERAPEUTIC AGENTS CONJUGATED TO ANTI-MATRIPTASE ANTIBODIES BY IN VIVO CLEAVABLE LINKING MOIETIES | Rutgers, the State University of New Jersey (US) | 2019-01-23 | — | — | EP | disclosed |
| WO-2017161288-A1 | TARGETING TUMOR CELLS WITH CHEMOTHERAPEUTIC AGENTS CONJUGATED TO ANTI-MATRIPTASE ANTIBODIES BY IN VIVO CLEAVABLE LINKING MOIETIES | RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) | 2017-09-21 | — | — | WO | disclosed |