Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.52 |
| ▸ | HTR2A | P28223 | 1/20 | 0.52 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.52 |
| ▸ | MLLT1 | Q03111 | 3/20 | 0.52 |
| ▸ | MLLT3 | P42568 | 1/20 | 0.52 |
| ▸ | YEATS2 | Q9ULM3 | 1/20 | 0.52 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.52 |
| ▸ | DRD4 | P21917 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.49 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15513484 | 0.95 | HRH3 (0.60) | NCF1HTR1AHTR7HDAC1HDAC8 | |
| SCHEMBL27678490 | 0.85 | ALDH1A1 (0.71) | ALDH1A1MLLT1HRH3KMT2A | |
| SCHEMBL2236992 | 0.81 | ALDH1A1 (0.65) | NCF1HDAC1HDAC8HDAC6ALDH1A1 | |
| SCHEMBL1936132 | 0.80 | MCHR1 (0.61) | HDAC1HDAC8HDAC6ALDH1A1CHRM1 | |
| SCHEMBL21392801 | 0.80 | NCF1 (0.56) | NCF1HTR1AHTR7HDAC1HDAC8 | |
| SCHEMBL5500400 | 0.80 | ALDH1A1 (0.68) | NCF1HDAC1HDAC8HDAC6ALDH1A1 | |
| SCHEMBL11533429 | 0.79 | CYP2C9 (0.65) | HDAC1HDAC6ALDH1A1MEN1KMT2A | |
| SCHEMBL3440319 | 0.79 | NCF1 (0.58) | NCF1HDAC1HDAC8HDAC6ALDH1A1 | |
| SCHEMBL26096917 | 0.78 | ALDH1A1 (0.62) | ALDH1A1 | |
| SCHEMBL22145190 | 0.77 | ALDH1A1 (0.76) | HTR1AHTR7HDAC1HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | EVOTEC AG (DE) | 2014-03-13 | — | — | US | disclosed |
| EP-2331518-A1 | NEW BRADYKININ B1 ANTAGONISTS | Evotec AG (DE) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010020556-A1 | NEW BRADYKININ B1 ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140073627-A1 | BRADYKININ B1 ANTAGONISTS | BDKRB1, BDKRB2, BRS3 | NCF1 1517/4885HTR1A 298/4885HTR7 1284/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.